Tuberc Respir Dis.  2006 Aug;61(2):162-166.

A Case of Multiple Endobronchial Metastases from Prostatic Carcinoma

• Lee JE
• Lee YJ
• Jeong MK
• Park HS
• Jung SS
• Kim JO
• Kang DY
• Sul CK
• Kim SY

Abstract

The lung is the most common site for the metastasis of extrapulmonary malignant tumors. However, endobronchial metastases (EBM) from extrapulmonary malignant tumors are rare. The most common extrathoracic malignancies associated with EBM are the breast, renal and colorectal carcinomas. Lung metastasis from prostate cancer is often encountered but EBM is rare. We report a 74-year old man with endobronchial metastases from prostatic carcinoma presented with cough. The diagnosis of prostatic cancer and the endobronchial metastasis were confirmed by immunohistological staining with the prostate specific antigen. Hormonal therapy (lutenizing hormone releasing hormone agonist) was applied to this patient.

Keyword

Multiple endobronchial metastases; Prostatic cancer

MeSH Terms

Aged
Breast
Colorectal Neoplasms
Cough
Diagnosis
Humans
Lung
Neoplasm Metastasis*
Prostate-Specific Antigen
Prostatic Neoplasms
Prostate-Specific Antigen

Figure

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  Figure 1 Chest X-ray showed no definitive parenchymal lesions. Pleural effusion was located in right lung.

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  Figure 2 Chest CT scan revealed loculated pleural effusion on right side. There was no definitive parenchymal lesion and no enlarged lymph nodes. There was bony mentastasis in thoracic vertebrae producing cord compression. (arrow).

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  Figure 3 Whole body bone scan showed multiple bony metastases.

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  Figure 4 Pelvic CT showed normal prostate.

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  Figure 5 Bronchoscopic finding showed multiple nodular masses in trachea (A), right (B) and left main bronchus (C), and single polypoid mass in right middle lobe brochus (right lower panel).

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  Figure 6 Representative hematoxylin/eosin-stained sections of the endobronchial mucosal lesion showed diffuse infiltration of well differentiated adenocarcinoma cells. (Left panel ×40, Right panel ×200).

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  Figure 7 Representative hematoxylin/eosin-stained sections of the prostate tissue showed neoplastic proliferation of glandular epithelial cells (×100).

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  Figure 8 Representative light microscopy of PSA-positive cells in the bronchial tissue. The brown color indicates PSA-positive cells (×200).

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