Tuberc Respir Dis.  2005 Nov;59(5):561-565.

A Case of Bronchiolitis Obliterans Organizing Pneumonia Following CHOP Chemotherapy and Filgrastim Use in a Patient with Diffuse Large B-cell Lymphoma

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ms70l@yumc.yonsei.ac.kr
  • 2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
  • 3The Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea.
  • 4Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
  • 5Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Bronchiolitis obliterans organizing pneumonia (BOOP) is often diagnosed in patients with pneumonia who respond poorly to antibiotics. BOOP is often idiopathic, and the etiology of the remaining cases has been attributed to a wide range of agents or medical conditions. When a patient develops the clinical symptoms characteristic of BOOP, the medical team must endeavor to determine the etiology of this disease because it can be treated with glucocorticoid and avoidance of the causative agent. In particular, if BOOP is diagnosed during or after chemotherapy for a malignancy, the possible culprit agent can be the anti cancer drugs but other drugs used for supportive care must be also be considered. We report a case of BOOP that arose after CHOP chemotherapy and a filgrastim injection in a patient with a diffuse large B-cell lymphoma.

Keyword

Bronchiolitis obliterans organizing pneumonia; Diffuse large B-cell lymphoma; CHOP; Filgrastim

MeSH Terms

Anti-Bacterial Agents
B-Lymphocytes*
Bronchiolitis Obliterans*
Bronchiolitis*
Cryptogenic Organizing Pneumonia*
Drug Therapy*
Humans
Lymphoma, B-Cell*
Pneumonia
Filgrastim
Anti-Bacterial Agents
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