Tuberc Respir Dis.  1999 Sep;47(3):394-399.

A Case of Pulmonary Thromboembolism due to Congenital Antithrombin III Deficiency

Affiliations
  • 1Pulmonary Department of Internal Medicine, Chonnam University Medical school, Kwangju, Korea. phkhs@unitel.co.kr

Abstract

We report a case of congenital and familial antithrombin III deficiency developing massive pulmonary thromboembolism. A 44-year-old man was admitted to our hospital because of sudden chest pain and severe dyspnea. Five years ago, he was operated due to a mesenteric vein thrombosis of unknown cause. On admission, radioisotopic venogram showed deep vein thrombosis and lung scintigram showed multiple segmental perfusion defects. His plasma antithrombin III level was 10.5 mg/dL which was less than 50% of normal and those of a son and two daughters were also decreased. After treatment with tissue plasminogen activator, heparin and coumadin, his symptom and lung scintigram were significantly improved. As far as we reviewed, there were very rare reports with congenital antithrombin III deficiency presenting as pulmonary thromboembolism in Korea.

Keyword

Antithrombin III; Pulmonary thromboembolism; Congenital

MeSH Terms

Adult
Antithrombin III
Antithrombin III Deficiency*
Chest Pain
Dyspnea
Heparin
Humans
Korea
Lung
Mesenteric Veins
Nuclear Family
Perfusion
Plasma
Pulmonary Embolism*
Thrombosis
Tissue Plasminogen Activator
Venous Thrombosis
Warfarin
Antithrombin III
Heparin
Tissue Plasminogen Activator
Warfarin
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