Tuberc Respir Dis.  1995 Aug;42(4):610-617.

Continuous Positive Airway Pressure Therapy in a Obstructive SleepApnea Syndrome associated with Active Acromegaly

• Moon HS
• Choi YM
• Ahn SJ
• Kim CH
• Kwon SS
• Kim YK
• Kim KH
• Song JS
• Park SH

Abstract

Sleep apnea occurs in approximately 50% of patients with acromegaly, and sleep apnea is associated with increased cardiovascular diseases and mortality. In view of these findings, sleep apnea may be a factor in the increased incidence of cardiovascular deaths in acromegaly patients. We experienced a case of active acromegaly patient, 54-yr-old man, associated with obstructive sleep apnea syndrome, congestive heart failure with dilated cardiomyopathy and serious cardiac arrhythmias. He was treated for obstructive sleep apnea syndrome, diagnosed by overnight polysomnography, with nasal continuous positive airway pressure(CPAP) for 4 months, which successfully controlled his loud snoring, sleep apnea, nocturnal hypoxemia and apnea-related symptoms. And also he was treated for underlying acromegaly and cardiac complications with bromocriptine and cardiogenic drugs for 4 months, but still had elevated growth hormone(GH) and insulin like growth factor-1 (IGF-1) levels and serious cardiac arrhythmias. We describe our experience about the effect of CPAP treatment in an active acromegaly patient associated with obstructive sleep apnea syndrome and cardiac complications with review of literature.

Keyword

Acromegaly; Sleep apnea; CPAP

MeSH Terms

Acromegaly*
Anoxia
Arrhythmias, Cardiac
Bromocriptine
Cardiomyopathy, Dilated
Cardiovascular Diseases
Continuous Positive Airway Pressure*
Heart Failure
Humans
Incidence
Insulin
Mortality
Polysomnography
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Snoring
Bromocriptine
Insulin