Saf Health Work.  2015 Sep;6(3):184-191. 10.1016/j.shaw.2015.05.005.

A Review on Mutagenicity Testing for Hazard Classification of Chemicals at Work: Focusing on in vivo Micronucleus Test for Allyl Chloride

• Rim KT
• Kim SJ

• KMID: 2317194
• DOI: http://doi.org/10.1016/j.shaw.2015.05.005

Abstract

Chemical mutagenicity is a major hazard that is important to workers' health. Despite the use of large amounts of allyl chloride, the available mutagenicity data for this chemical remains controversial. To clarify the mutagenicity of allyl chloride and because a micronucleus (MN) test had not yet been conducted, we screened for MN induction by using male ICR mice bone marrow cells. The test results indicated that this chemical is not mutagenic under the test conditions. In this paper, the regulatory test battery and several assay combinations used to determine the genotoxic potential of chemicals in the workplace have been described. Further application of these assays may prove useful in future development strategies of hazard evaluations of industrial chemicals. This study also should help to improve the testing of this chemical by commonly used mutagenicity testing methods and investigations on the underlying mechanisms and could be applicable for workers' health.

Keyword

allyl chloride; Globally Harmonized System of Classification and Labeling of Chemicals; micronucleus; mutagenicity; occupational disease

MeSH Terms

Animals
Bone Marrow Cells
Classification*
Humans
Male
Mice
Mice, Inbred ICR
Micronucleus Tests*
Mutagenicity Tests*
Occupational Diseases