Psychiatry Investig.  2016 Mar;13(2):217-221. 10.4306/pi.2016.13.2.217.

Sleep EEG Characteristics in Young and Elderly Patients with Obstructive Sleep Apnea Syndrome

Affiliations
  • 1Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University College of Medicine, Seoul, Republic of Korea. jeongdu@snu.ac.kr
  • 2NHMRC Centre for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
  • 3School of Physics, The University of Sydney, Sydney, Australia.
  • 4Department of Psychiatry, Seoul Metropolitan Eunpyeong Hospital, Seoul, Republic of Korea.

Abstract


OBJECTIVE
In the present study, it was hypothesized that the sleep electroencephalogram (EEG) characteristics of young (<30 yrs) and elderly (>55 yrs) OSAS patients would differ.
METHODS
We analyzed 76 sleep EEG recordings from OSAS patients (young group: n=40, mean age: 24.3±4.9 yrs; elderly group: n=36, mean age: 59.1±4.9 yrs), which were obtained during nocturnal polysomnography. The recordings were assessed via spectral analysis in the delta (0.5-4.5 Hz), theta (4.5-8 Hz), alpha (8-12 Hz), beta (12-32 Hz), slow sigma (11-13 Hz), and fast sigma (13-17 Hz) frequency bands.
RESULTS
Apnea Hypopnea Index (AHI) and sleep efficiency (%) did not differ significantly between the two groups (19.8±14.4 vs. 25.9±16.0, p=0.085; 84.4±12.6 vs. 80.9±11.0, p=0.198, respectively). After adjusting for gender, the slow/fast sigma ratio was not significantly correlated with AHI in the elderly group (r=-0.047, p=0.790) but AHI was inversely correlated with the slow/fast sigma ratio in the young group (r=-0.423, p=0.007). A multiple linear regression analysis revealed that a higher AHI was related with a lower slow/fast sigma ratio in the young group (β=-0.392, p=0.028) but not the elderly.
CONCLUSION
In the present study, sleep EEG activity differed between young and elderly OSAS patients. The slow/fast sigma ratio was associated with OSAS severity only in young patients, suggesting that young OSAS patients may have a distinctive brain plasticity compared with elderly patients.

Keyword

OSAS; Sleep EEG; Sleep spindle

MeSH Terms

Aged*
Apnea
Brain
Electroencephalography*
Humans
Linear Models
Plastics
Polysomnography
Sleep Apnea, Obstructive*
Plastics
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