Korean J Urol.  2013 Sep;54(9):570-579.

Technical Aspects of Holmium Laser Enucleation of the Prostate for Benign Prostatic Hyperplasia

Affiliations
  • 1Department of Urology, Seoul National University Hospital, Seoul, Korea. sjo@snu.ac.kr

Abstract

Holmium laser enucleation of the prostate (HoLEP) is a minimally invasive procedure and a size-independent treatment for benign prostatic hyperplasia with excellent long-term surgical outcome. HoLEP has become an alternative to conventional transurethral resection of the prostate or open prostatectomy owing to its efficacy and safety. Although HoLEP is known to have a steep learning curve, very few articles have addressed the technical aspects of HoLEP. Herein, we described detailed techniques and tips for HoLEP as performed at Seoul National University Hospital in a step-by-step manner with extensive review of the literature.

Keyword

Holmium laser enucleation of the prostate; Morcellation; Prostate surgery; Prostatic hyperplasia; Surgical procedure

MeSH Terms

Holmium
Lasers, Solid-State
Learning Curve
Prostate
Prostatectomy
Prostatic Hyperplasia
Holmium

Figure

  • FIG. 1 Two different types of working channels for holmium laser enucleation of the prostate. (A) An Iglesias type resectoscope. (B) A conventional laser fiber stabilizing bridge.

  • FIG. 2 Hand manipulation for holmium laser enucleation of the prostate. (A) Enucleation. (B) Morcellation.

  • FIG. 3 The three-lobe or four-lobe technique. Step A, initial incision; step B, transverse incision for median lobe enucleation; step C, upward enucleation of both lateral lobes; step D, longitudinal incision of the anterior lobe (12 o'clock position); step E, downward enucleation of both lateral lobes; step F, completion of lateral lobe enucleation; step G, anterior lobe removal during the four-lobe technique.


Reference

1. Geavlete B, Stanescu F, Iacoboaie C, Geavlete P. Bipolar plasma enucleation of the prostate vs open prostatectomy in large benign prostatic hyperplasia cases: a medium term, prospective, randomized comparison. BJU Int. 2013; 111:793–803.
2. McVary KT, Roehrborn CG, Avins AL, Barry MJ, Bruskewitz RC, Donnell RF, et al. Update on AUA guideline on the management of benign prostatic hyperplasia. J Urol. 2011; 185:1793–1803.
3. Mebust WK, Holtgrewe HL, Cockett AT, Peters PC. Transurethral prostatectomy: immediate and postoperative complications: a cooperative study of 13 participating institutions evaluating 3,885 patients. J Urol. 1989; 141:243–247.
4. Roos NP, Wennberg JE, Malenka DJ, Fisher ES, McPherson K, Andersen TF, et al. Mortality and reoperation after open and transurethral resection of the prostate for benign prostatic hyperplasia. N Engl J Med. 1989; 320:1120–1124.
5. Ansari MZ, Costello AJ, Jolley DJ, Ackland MJ, Carson N, McDonald IG. Adverse events after prostatectomy in Victorian public hospitals. Aust N Z J Surg. 1998; 68:830–836.
6. Holtgrewe HL, Valk WL. Factors influencing the mortality and morbidity of transurethral prostatectomy: a study of 2,015 cases. J Urol. 1962; 87:450–459.
7. Gilling PJ, Cass CB, Malcolm AR, Fraundorfer MR. Combination holmium and Nd:YAG laser ablation of the prostate: initial clinical experience. J Endourol. 1995; 9:151–153.
8. Teichmann HO, Herrmann TR, Bach T. Technical aspects of lasers in urology. World J Urol. 2007; 25:221–225.
9. Gilling PJ, Cass CB, Cresswell MD, Fraundorfer MR. Holmium laser resection of the prostate: preliminary results of a new method for the treatment of benign prostatic hyperplasia. Urology. 1996; 47:48–51.
10. Fraundorfer MR, Gilling PJ. Holmium:YAG laser enucleation of the prostate combined with mechanical morcellation: preliminary results. Eur Urol. 1998; 33:69–72.
11. Wilson LC, Gilling PJ, Williams A, Kennett KM, Frampton CM, Westenberg AM, et al. A randomised trial comparing holmium laser enucleation versus transurethral resection in the treatment of prostates larger than 40 grams: results at 2 years. Eur Urol. 2006; 50:569–573.
12. Montorsi F, Naspro R, Salonia A, Suardi N, Briganti A, Zanoni M, et al. Holmium laser enucleation versus transurethral resection of the prostate: results from a 2-center prospective randomized trial in patients with obstructive benign prostatic hyperplasia. J Urol. 2008; 179:5 Suppl. S87–S90.
13. Gupta N, Sivaramakrishna , Kumar R, Dogra PN, Seth A. Comparison of standard transurethral resection, transurethral vapour resection and holmium laser enucleation of the prostate for managing benign prostatic hyperplasia of >40 g. BJU Int. 2006; 97:85–89.
14. Tan A, Liao C, Mo Z, Cao Y. Meta-analysis of holmium laser enucleation versus transurethral resection of the prostate for symptomatic prostatic obstruction. Br J Surg. 2007; 94:1201–1208.
15. Kuntz RM, Lehrich K. Transurethral holmium laser enucleation versus transvesical open enucleation for prostate adenoma greater than 100 gm: a randomized prospective trial of 120 patients. J Urol. 2002; 168(4 Pt 1):1465–1469.
16. Reich O, Gratzke C, Stief CG. Techniques and long-term results of surgical procedures for BPH. Eur Urol. 2006; 49:970–978.
17. Fraundorfer MR, Gilling PJ, Kennett KM, Dunton NG. Holmium laser resection of the prostate is more cost effective than transurethral resection of the prostate: results of a randomized prospective study. Urology. 2001; 57:454–458.
18. Kabalin JN, Gilling PJ, Fraundorfer MR. Application of the holmium: YAG laser for prostatectomy. J Clin Laser Med Surg. 1998; 16:21–27.
19. Elzayat EA, Elhilali MM. Holmium laser enucleation of the prostate (HoLEP): long-term results, reoperation rate, and possible impact of the learning curve. Eur Urol. 2007; 52:1465–1471.
20. Kuntz RM, Lehrich K, Ahyai SA. Holmium laser enucleation of the prostate versus open prostatectomy for prostates greater than 100 grams: 5-year follow-up results of a randomised clinical trial. Eur Urol. 2008; 53:160–166.
21. Moody JA, Lingeman JE. Holmium laser enucleation for prostate adenoma greater than 100 gm: comparison to open prostatectomy. J Urol. 2001; 165:459–462.
22. Tan AH, Gilling PJ. Holmium laser prostatectomy: current techniques. Urology. 2002; 60:152–156.
23. Shah HN, Mahajan AP, Sodha HS, Hegde S, Mohile PD, Bansal MB. Prospective evaluation of the learning curve for holmium laser enucleation of the prostate. J Urol. 2007; 177:1468–1474.
24. Seki N, Mochida O, Kinukawa N, Sagiyama K, Naito S. Holmium laser enucleation for prostatic adenoma: analysis of learning curve over the course of 70 consecutive cases. J Urol. 2003; 170:1847–1850.
25. El-Hakim A, Elhilali MM. Holmium laser enucleation of the prostate can be taught: the first learning experience. BJU Int. 2002; 90:863–869.
26. Shah HN, Hegde SS, Shah JN, Mahajan AP, Bansal MB. Simultaneous transurethral cystolithotripsy with holmium laser enucleation of the prostate: a prospective feasibility study and review of literature. BJU Int. 2007; 99:595–600.
27. Hochreiter WW, Thalmann GN, Burkhard FC, Studer UE. Holmium laser enucleation of the prostate combined with electrocautery resection: the mushroom technique. J Urol. 2002; 168(4 Pt 1):1470–1474.
28. Shah HN, Mahajan AP, Hegde SS, Bansal MB. Peri-operative complications of holmium laser enucleation of the prostate: experience in the first 280 patients, and a review of literature. BJU Int. 2007; 100:94–101.
29. Kuo RL, Paterson RF, Kim SC, Siqueira TM Jr, Elhilali MM, Lingeman JE. Holmium laser enucleation of the prostate (HoLEP): a technical update. World J Surg Oncol. 2003; 1:6.
30. Madersbacher S, Alivizatos G, Nordling J, Sanz CR, Emberton M, de la Rosette JJ. EAU 2004 guidelines on assessment, therapy and follow-up of men with lower urinary tract symptoms suggestive of benign prostatic obstruction (BPH guidelines). Eur Urol. 2004; 46:547–554.
31. Gilling PJ, Kennett K, Das AK, Thompson D, Fraundorfer MR. Holmium laser enucleation of the prostate (HoLEP) combined with transurethral tissue morcellation: an update on the early clinical experience. J Endourol. 1998; 12:457–459.
32. Aho TF, Gilling PJ. Current techniques for laser prostatectomy: PVP and HoLEP. Arch Esp Urol. 2008; 61:1005–1013.
33. Oelke M, Hofner K, Wiese B, Grunewald V, Jonas U. Increase in detrusor wall thickness indicates bladder outlet obstruction (BOO) in men. World J Urol. 2002; 19:443–452.
34. Diokno AC, Wells TJ, Brink CA. Comparison of self-reported voided volume with cystometric bladder capacity. J Urol. 1987; 137:698–700.
35. Ertberg P, Moller LA, Lose G. A comparison of three methods to evaluate maximum bladder capacity: cystometry, uroflowmetry and a 24-h voiding diary in women with urinary incontinence. Acta Obstet Gynecol Scand. 2003; 82:374–377.
36. Rieken M, Ebinger Mundorff N, Bonkat G, Wyler S, Bachmann A. Complications of laser prostatectomy: a review of recent data. World J Urol. 2010; 28:53–62.
37. Descazeaud A, Robert G, Azzousi AR, Ballereau C, Lukacs B, Haillot O, et al. Laser treatment of benign prostatic hyperplasia in patients on oral anticoagulant therapy: a review. BJU Int. 2009; 103:1162–1165.
38. Gilling PJ, Kennett KM, Fraundorfer MR. Holmium laser enucleation of the prostate for glands larger than 100 g: an endourologic alternative to open prostatectomy. J Endourol. 2000; 14:529–531.
39. Tan AH, Gilling PJ, Kennett KM, Frampton C, Westenberg AM, Fraundorfer MR. A randomized trial comparing holmium laser enucleation of the prostate with transurethral resection of the prostate for the treatment of bladder outlet obstruction secondary to benign prostatic hyperplasia in large glands (40 to 200 grams). J Urol. 2003; 170(4 Pt 1):1270–1274.
40. Elzayat EA, Habib EI, Elhilali MM. Holmium laser enucleation of the prostate: a size-independent new "gold standard". Urology. 2005; 66:5 Suppl. 108–113.
41. Krambeck AE, Handa SE, Lingeman JE. Experience with more than 1,000 holmium laser prostate enucleations for benign prostatic hyperplasia. J Urol. 2013; 189:1 Suppl. S141–S145.
42. Gong YG, He DL, Wang MZ, Li XD, Zhu GD, Zheng ZH, et al. Holmium laser enucleation of the prostate: a modified enucleation technique and initial results. J Urol. 2012; 187:1336–1340.
43. Bae J, Choo M, Park JH, Oh JK, Paick JS, Oh SJ. Holmium laser enucleation of prostate for benign prostatic hyperplasia: seoul national university hospital experience. Int Neurourol J. 2011; 15:29–34.
44. Aho TF, Gilling PJ, Kennett KM, Westenberg AM, Fraundorfer MR, Frampton CM. Holmium laser bladder neck incision versus holmium enucleation of the prostate as outpatient procedures for prostates less than 40 grams: a randomized trial. J Urol. 2005; 174:210–214.
45. Kuntz RM, Lehrich K, Ahyai S. Does perioperative outcome of transurethral holmium laser enucleation of the prostate depend on prostate size? J Endourol. 2004; 18:183–188.
46. Kuntz RM, Lehrich K, Ahyai S. Transurethral holmium laser enucleation of the prostate compared with transvesical open prostatectomy: 18-month follow-up of a randomized trial. J Endourol. 2004; 18:189–191.
47. Kim SH, Lee HE, Kwak C, Kim SW, Kim HH, Paick JS, et al. Holmium laser enucleation prostatectomy in very large prostates [abstract]. J Urol. 2013; 189:e164. Meeting abstract no. V404.
48. Matlaga BR, Kim SC, Kuo RL, Watkins SL, Lingeman JE. Holmium laser enucleation of the prostate for prostates of >125 mL. BJU Int. 2006; 97:81–84.
49. Elzayat EA, Elhilali MM. Holmium laser enucleation of the prostate (HoLEP): the endourologic alternative to open prostatectomy. Eur Urol. 2006; 49:87–91.
50. Tooher R, Sutherland P, Costello A, Gilling P, Rees G, Maddern G. A systematic review of holmium laser prostatectomy for benign prostatic hyperplasia. J Urol. 2004; 171:1773–1781.
51. Gomez Sancha F, Bachmann A, Choi BB, Tabatabaei S, Muir GH. Photoselective vaporization of the prostate (GreenLight PV): lessons learnt after 3500 procedures. Prostate Cancer Prostatic Dis. 2007; 10:316–322.
52. Clayman RV, Kavoussi LR, Long SR, Dierks SM, Meretyk S, Soper NJ. Laparoscopic nephrectomy: initial report of pelviscopic organ ablation in the pig. J Endourol. 1990; 4:247–252.
53. Cuschieri A, Frank T. Slicer and tissue retrieval system for excisional endoscopic surgery. Surg Endosc. 1994; 8:1246–1249.
54. Steiner RA, Wight E, Tadir Y, Haller U. Electrical cutting device for laparoscopic removal of tissue from the abdominal cavity. Obstet Gynecol. 1993; 81:471–474.
55. Hoffman MS, DeCesare S, Kalter C. Abdominal hysterectomy versus transvaginal morcellation for the removal of enlarged uteri. Am J Obstet Gynecol. 1994; 171:309–313.
56. Hurle R, Vavassori I, Piccinelli A, Manzetti A, Valenti S, Vismara A. Holmium laser enucleation of the prostate combined with mechanical morcellation in 155 patients with benign prostatic hyperplasia. Urology. 2002; 60:449–453.
57. Jeong CW, Oh JK, Cho MC, Bae JB, Oh SJ. Enucleation ratio efficacy might be a better predictor to assess learning curve of holmium laser enucleation of the prostate. Int Braz J Urol. 2012; 38:362–371.
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