Korean J Urol.
2013 Oct;54(10):645-650.
Role of the Epithelial-Mesenchymal Transition in Bladder Cancer: From Prognosis to Therapeutic Target
- Affiliations
-
- 1Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea. wjkim@chungbuk.ac.kr
Abstract
- Bladder cancer (BC) is the second most common malignancy of urological organs. However, patients with non-muscle-invasive BC are at high risk of recurrence and progression into muscle-invasive BC, and the prognosis of patients with muscle-invasive BC is limited by the high rate of metastasis. The epithelial-mesenchymal transition (EMT) is characterized by loss of cell-to-cell adhesion and cell polarity and is closely associated with the invasion and metastasis of several cancers. Given the multifocality and high rates of relapse, progression, and metastasis of BC, the EMT is likely to participate in BC as well. Numerous factors associate with the EMT, and the key regulators of the EMT are E-cadherin, N-cadherin, Twist, Snail, Slug, Zeb-1, Zeb-2, vimentin, and microRNAs. This review focuses on the current concepts regarding the EMT in cancer and the evidence for involvement of the EMT in BC. Several potential EMT targets that may be useful in the treatment of BC are also described.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Modulation of PRL-1 in placental MSCs: A novel therapeutic strategy for hepatic fibrosis: Editorial on “Modulation of phosphatase of regenerating liver-1 within placental mesenchymal stem cells instigates the transition between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition subsequent to hepatic fibrosis”
- Role of Gastric Stem Cells in Gastric Carcinogenesis by Chronic Helicobacter pylori Infection
- Pancreatic Cancer and MicroRNAs
- Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer
- Epithelial-Mesenchymal Transition in Head and Neck Cancer
