Korean J Urol.  2011 Jul;52(7):498-501.

Bilateral Renal Choriocarcinoma in a Postmenopausal Woman

• Karadeniz
• Topsakal M
• Ozkaptan O
• Cakir C

Abstract

Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia. It grows rapidly and metastasizes to the lung, liver, and less frequently, the brain. Metastases to the kidney are rare in the literature, and bilateral involvement is even more scarce. Renal involvement of choriocarcinoma is highly exceptional and may mimic renal cell carcinoma. Here we report a case of bilateral renal choriocarcinoma presenting 5 years after a history of a total anterior hysterectomy because of a hydatidiform mole.

Keyword

Choriocarcinoma; Kidney neoplasms

MeSH Terms

Brain
Carcinoma, Renal Cell
Choriocarcinoma
Female
Gestational Trophoblastic Disease
Humans
Hydatidiform Mole
Hydrazines
Hysterectomy
Kidney
Kidney Neoplasms
Liver
Lung
Neoplasm Metastasis
Pregnancy
Hydrazines

Figure

• 

  FIG. 1 Abdominal CT scan showing bilateral renal masses.

• 

  FIG. 2 Peripheral nodular lesions on both lungs (black arrows).

• 

  FIG. 3 Histological sections showing. (A) H&E (×10), (B) Inhibin staining of syncytiotrophoblasts (×20), (C) Tumor cells stained with b-hcg (×10).

Reference

1. Dilek S, Pata O, Tok E, Polat A. Extraovarian nongestational choriocarcinoma in a postmenopausal woman. Int J Gynecol Cancer. 2004. 14:1033–1035.

2. O'Neill CJ, Houghton F, Clarke J, McCluggage WG. Uterine gestational choriocarcinoma developing after a long latent period in a postmenopausal woman: the value of DNA polymorphism studies. Int J Surg Pathol. 2008. 16:226–229.

3. Sonobe H, Taguchi K, Ogawa K, Yoshioka T. Latent vaginal choriocarcinoma in a postmenopausal woman. Acta Pathol Jpn. 1976. 26:611–618.

4. Savage P. Hancock BW, Seckl MJ, Berkowitz RS, Cole LA, editors. Clinical features of molar pregnancies and gestational trophoblastic neoplasia. Gestational trophoblastic disease. 2011. 3rd ed. 216–248.

5. Small W Jr, Lurain JR, Shetty RM, Huang CF, Applegate GL, Brand WN. Gestational trophoblastic disease metastatic to the brain. Radiology. 1996. 200:277–280.

6. Mastrodomenico I, Korobkin M, Silverman PM, Dunnick NR. Perinephric hemorrhage from metastatic carcinoma to the kidney. J Comput Assist Tomogr. 1983. 7:727–729.

7. Wang YE, Song HZ, Yang XY, Dong SY, Gan N. Renal metastasis of choriocarcinoma. A clinicopathological study of 31 cases. Chin Med J. 1991. 104:716–720.

8. Ngan HY, Benedet JL, Jones HW III, Bender HG, Pecorelli S. FIGO Staging and risk factor scoring for trophoblastic neoplasia. Int J Gynecol Obstet. 2002. 77:285–287.

9. Alazzam M, Tidy J, Hancock BW, Osborne R. First line chemotherapy in low risk gestational trophoblastic neoplasia. Cochrane Database Syst Rev. 2009. 1:CD007102.

10. Lurain JR, Singh DK, Schink JC. Role of surgery in the management of high-risk gestational trophoblastic neoplasia. J Reprod Med. 2006. 51:773–776.