J Gynecol Oncol.  2009 Sep;20(3):192-194. 10.3802/jgo.2009.20.3.192.

A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman

• Park SH
• Park A
• Kim JY
• Kwon JH
• Koh SB

• KMID: 2173454
• DOI: http://doi.org/10.3802/jgo.2009.20.3.192

Abstract

Primary ovarian choriocarcinoma arising from a germ cell is an extremely rare occurrence, especially in postmenopausal women, and the prognosis is poor. Non-gestational choriocarcinoma of the ovary (NGCO) accounts for 0.6% or less of all ovarian neoplasms. It is important to distinguish gestational choriocarcinomas of the ovary (GCO) from other carcinomas because of the poor prognosis of NGCO. We describe a case of NGCO with lung metastasis in a 55 year old woman, which we present together with a brief review of the literature.

Keyword

Nongestational choriocarcinoma; Ovary; Postmenopause

MeSH Terms

Choriocarcinoma
Choriocarcinoma, Non-gestational
Female
Germ Cells
Humans
Lung
Neoplasm Metastasis
Ovarian Neoplasms
Ovary
Postmenopause
Pregnancy
Prognosis

Figure

• 

  Fig. 1 Microscopic findings: the tumor is composed of syncytiotrophoblast and cytotrophoblast with hemorrhage (H-E stain, ×100).

Reference

1. Jacobs AJ, Newland JR, Green RK. Pure choriocarcinoma of the ovary. Obstet Gynecol Surv. 1982. 37:603–609.

2. Tsujioka H, Hamada H, Miyakawa T, Hachisuga T, Kawarabayashi T. A pure nongestational choriocarcinoma of the ovary diagnosed with DNA polymorphism analysis. Gynecol Oncol. 2003. 89:540–542.

3. Yamamoto E, Ino K, Yamamoto T, Sumigama S, Nawa A, Nomura S, et al. A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature. Int J Gynecol Cancer. 2007. 17:254–258.

4. Jacobs AJ, Newland JR, Green RK. Pure choriocarcinoma of the ovary. Obstet Gynecol Surv. 1982. 37:603–609.

5. Vance RP, Geisinger KR. Pure nongestational choriocarcinoma of the ovary: report of a case. Cancer. 1985. 56:2321–2325.

6. Byeun TS, Byeun C, Chung DY, Park TC, Ahn WS, Lee JW, et al. A case of primary ovarian carcinoma. Korean J Obstet Gynecol. 1995. 38:1713–1717.

7. Kim KS, Kim JH, Jung MJ, Oh BC. Primary ovarian non-gestational choriocarcinoma in a young woman. Korean J Obstet Gynecol. 1997. 40:1802–1807.

8. Shin YS, You HI, Lim OR, Park SY, Kim YT, Lee KW. A case of primary ovarian choriocarcinoma. Korean J Obstet Gynecol. 1994. 37:592–596.

9. Kim PS, Kim SC, Kim JH, Choi YM, Lee HP. Pure choriocarcinoma of ovary. Korean J Obstet Gynecol. 1990. 33:1607–1611.

10. Hirabayashi K, Yasuda M, Osamura RY, Hirasawa T, Murakami M. Ovarian nongestational choriocarcinoma mixed with various epithelial malignancies in association with endometriosis. Gynecol Oncol. 2006. 102:111–117.

11. Weiss S, Amit A, Schwartz MR, Kaplan AL. Primary choriocarcinoma of the vulva. Int J Gynecol Cancer. 2001. 11:251–254.

12. Hammond CB, Schmidt HJ, Parker RT. McGowan L, editor. Gestational trophoblastic: disease. Gynecologic oncology. 1978. New York: Appleton-Century-Crofts;359–381.

13. Massenkeil G, Crombach G, Dominik S, De Bruyne F, Nitz U, Krussel J, et al. Metastatic choriocarcinoma in a postmenopausal woman. Gynecol Oncol. 1996. 61:432–437.