Pediatr Allergy Respir Dis.  2012 Dec;22(4):433-437.

A Case of Bronchiolitis Obliterans Organizing Pneumonia with a Solitary Pulmonary Nodule in a Child

Affiliations
  • 1Department of Pediatrics, Kwangju Christian Hospital, Gwangju, Korea. drcho92@hanmail.net
  • 2Department of Pediatrics, Chounnam National University Collage of Medicine, Gwangju, Korea.

Abstract

Bronchiolitis obliterans organizing pneumonia (BOOP) is a pulmonary disorder that exhibits various radiographic findings. It often shows bilateral, patched, or ground glass interstitial infiltrate, but a solitary nodular pattern rarely appears. We report a case of an 8-year-old boy suffering from BOOP that showed a single nodular pattern of the lung in the chest radiography. We conclude that when there is a solitary nodule discovered in the lungs of children or adolescence, the differential diagnosis must include BOOP.

Keyword

Bronchiolitis obliterans organizing pneumonia; Pulmonary solitary nodule

MeSH Terms

Adolescent
Bronchiolitis
Bronchiolitis Obliterans
Child
Cryptogenic Organizing Pneumonia
Diagnosis, Differential
Glass
Humans
Lung
Solitary Pulmonary Nodule
Stress, Psychological
Thorax

Figure

  • Fig. 1 Chest radiograph showed a round shaped mass like consolidation in the right lower lobe at hospital day 1.

  • Fig. 2 Chest computer tomography image showed a 3.5 cm sized mass with ground glass opacity, containing focal calcification in the right lower lobe.

  • Fig. 3 (A) The biopsy specimen showed aninflammation in the surrounding alveoli, with thickening alveolar walls with lymphoid cell infiltration (H&E, ×100). (B) Granulation tissue in the bronchiolar lumen, alveolar ducts, and some alveoli in polypoid shape (H&E, ×200).

  • Fig. 4 Follow-up chest radiograph, at 2 years later after the surgical excision, showed that the round shaped mass in the right lower lobe had completely disappeared. No relapse occurred.


Reference

1. Epler GR, Colby TV, McLoud TC, Carrington CB, Gaensler EA. Bronchiolitis obliterans organizing pneumonia. N Engl J Med. 1985. 312:152–158.
Article
2. Izumi T, Kitaichi M, Nishimura K, Nagai S. Bronchiolitis obliterans organizing pneumonia. Clinical features and differential diagnosis. Chest. 1992. 102:715–719.
3. Kohno N, Ikezoe J, Johkoh T, Takeuchi N, Tomiyama N, Kido S, et al. Focal organizing pneumonia: CT appearance. Radiology. 1993. 189:119–123.
Article
4. Leonidas JC. Pneumonia presenting as a radiographic mass in a child. Mt Sinai J Med. 1986. 53:489–490.
5. Restrepo R, Palani R, Matapathi UM, Wu YY. Imaging of round pneumonia and mimics in children. Pediatr Radiol. 2010. 40:1931–1940.
Article
6. Cordier JF. Organising pneumonia. Thorax. 2000. 55:318–328.
7. Cordier JF. Cryptogenic organising pneumonia. Eur Respir J. 2006. 28:422–446.
Article
8. Epler GR. Bronchiolitis obliterans organizing pneumonia. Arch Intern Med. 2001. 161:158–164.
Article
9. Cordier JF. Cryptogenic organizing pneumonia. Clin Chest Med. 2004. 25:727–738. vi–vii.
Article
10. Cordier JF, Loire R, Brune J. Idiopathic bronchiolitis obliterans organizing pneumonia. Definition of characteristic clinical profiles in a series of 16 patients. Chest. 1989. 96:999–1004.
Article
11. Flowers JR, Clunie G, Burke M, Constant O. Bronchiolitis obliterans organizing pneumonia: the clinical and radiological features of seven cases and a review of the literature. Clin Radiol. 1992. 45:371–377.
Article
12. Helton KJ, Kuhn JP, Fletcher BD, Jenkins JJ 3rd, Parham DM. Bronchiolitis obliterans-organizing pneumonia (BOOP) in children with malignant disease. Pediatr Radiol. 1992. 22:270–274.
Article
13. Maldonado F, Daniels CE, Hoffman EA, Yi ES, Ryu JH. Focal organizing pneumonia on surgical lung biopsy: causes, clinicoradiologic features, and outcomes. Chest. 2007. 132:1579–1583.
14. Inoue T, Toyoshima K, Kikui M. Idiopathic bronchiolitis obliterans organizing pneumonia (idiopathic BOOP) in childhood. Pediatr Pulmonol. 1996. 22:67–72.
Article
15. Choi BK, Kang TH, Bae KL, Hwang KG, Choi AH. A case of bronchiolitis obliterans organizing pneumonia. Pediatr Allergy Respir Dis. 1995. 5:153–159.
16. Lee BC, Kim HL, Shin KW, Hong SA, Choi BK, Kim HS, et al. A case of bronchiolitis obliterans organizing pneumonia developed after treatment of acute myelogenous leukemia (M2) with chloroma and retinopathy. Korean J Pediatr Hematol Oncol. 2004. 11:247–252.
17. Akira M, Yamamoto S, Sakatani M. Bronchiolitis obliterans organizing pneumonia manifesting as multiple large nodules or masses. AJR Am J Roentgenol. 1998. 170:291–295.
Article
18. Melloni G, Cremona G, Bandiera A, Arrigoni G, Rizzo N, Varagona R, et al. Localized organizing pneumonia: report of 21 cases. Ann Thorac Surg. 2007. 83:1946–1951.
Article
19. Zheng Z, Pan Y, Song C, Wei H, Wu S, Wei X, et al. Focal organizing pneumonia mimicking lung cancer: a surgeon's view. Am Surg. 2012. 78:133–137.
Article
Full Text Links
  • PARD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr