Korean J Urol.  2009 Jul;50(7):629-634.

Urologic Applications of Cryo-Immunology

• Sidana A
• Rodriguez

Abstract

PURPOSE
Cryoablation is gaining acceptance as a primary treatment of localized metastatic urologic malignancies as well as a salvage therapy. Anecdotal clinical reports suggest that cryoablation can induce a systemic antitumor immune response, which has been confirmed in animal models also. MATERIALS AND METHODS: A review of the relevant literature was performed to suggest urologic applications of cryo-immunology. RESULTS: This article reviews the existing evidence regarding cryo-immunology and discusses the mechanisms for generation of an anti-tumor immune response. CONCLUSIONS: Our findings suggest combining cryoablation with other immunotherapeutic approaches to devise a cryo-immunotherapeutic strategy with potential to impact the progression of metastatic disease.

Keyword

Cryosurgery; Prostatic neoplasms; Kidney neoplasms; Immunotherapy

MeSH Terms

Cryosurgery
Immunotherapy
Kidney Neoplasms
Models, Animal
Prostatic Neoplasms
Salvage Therapy

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