Korean J Urol.  2010 Dec;51(12):863-869.

Analysis of the Results of ABO-Incompatible Kidney Transplantation: In Comparison with ABO-Compatible Kidney Transplantation

• Jeon BJ
• Kim IG
• Seong YK
• Han BH

Abstract

PURPOSE
The number of patients waiting for kidney transplantation is incessantly increasing, but the number of cadaveric kidney transplantations or ABO-compatible donors is so insufficient that ABO-incompatible kidney transplantation is being performed as an alternative. There are overseas studies and research showing that the 5-year survival rate and 5-year graft survival rate of ABO-incompatible kidney transplantation are not much different from those of ABO-compatible kidney transplantation. However, domestic research on the subject is rare. Therefore, we report the results of 22 ABO-incompatible kidney transplantation cases performed in our hospital.
MATERIALS AND METHODS
This research was from 22 patients in our hospital who underwent ABO-incompatible kidney transplantation from 15 February 2007 to 20 May 2010.
RESULTS
As yet, there have been no donor graft losses and no deaths after transplantation. The results of the two groups were analyzed by analysis of covariance of the creatinine value of the recipients at 6 months after the operation, corrected for the preoperative value in order to statistically identify whether there were differences in renal function after the operation between ABO-compatible and ABO-incompatible kidney transplantation. The results of the analysis of covariance showed no statistical difference in renal function after the operation between the two groups.
CONCLUSIONS
Even though there were not many cases, our initial results for ABO-incompatible kidney transplantation were positive. Considering the increasing number of patients waiting for kidney transplantation, longer-term domestic research studies of ABO-incompatible kidney transplantation are necessary.

Keyword

ABO blood-group system; Kidney transplantation; Living donors

MeSH Terms

ABO Blood-Group System
Cadaver
Creatinine
Graft Survival
Humans
Kidney
Kidney Transplantation
Living Donors
Survival Rate
Tissue Donors
Transplants
ABO Blood-Group System
Creatinine

Figure

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  FIG. 1 Comparison of renal function after the operation between ABO-compatible and ABO-incompatible kidney transplantation; n=83 cases. Circles are compatible cases, and triangles are incompatible ones.

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  FIG. 2 Comparison of renal function after the operation between ABO-compatible and ABO-incompatible kidney transplantation: human leukocyte antigen (HLA) mismatch no. 5; n=23 cases.

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