Osteoporosis.  2015 Aug;13(1):36-44. 10.0000/ost.2015.13.1.36.

Associations of Low Bone Mass with High Serum Ferritin in the Korean General Female Population: Analysis of 2008-2010 Korean National Health and Nutrition Examination Survey Data

• Lee BK
• Kim Y

• KMID: 2314155
• DOI: http://doi.org/10.0000/ost.2015.13.1.36

Abstract

OBJECTIVES
The present study was performed to evaluate the association between serum ferritin concentrations and bone mineral density (BMD) in a representative Korean general population.
METHODS
This was a cross-sectional study based on data obtained in the Korean National Health and Nutrition Examination Survey (2008~2010). The present cross-sectional analysis was restricted to participants > or =20 years of age who completed the health examination survey and BMD measurement (n=15,538).
RESULTS
In multiple linear regression analysis of log2-transformed serum ferritin as a continuous variable on BMD, the differences in BMD levels associated with doubling of serum ferritin were -0.0022~-0.0057 in a large representative sample of South Korean women, but not in men. In this large representative sample of South Korean women, elevated serum ferritin level was consistently associated with the prevalence of low bone mass for chronological age. However, there were no significant associations of ferritin level and low bone mass in men.
CONCLUSION
An association of elevated ferritin level with lower BMD level was observed in the general female population. Thus, our results have substantial public health implications.

Keyword

Bone mineral density; Ferritin; Iron; Bone mass

MeSH Terms

Bone Density
Cross-Sectional Studies
Female*
Ferritins*
Humans
Iron
Linear Models
Male
Nutrition Surveys*
Prevalence
Public Health
Ferritins
Iron