Obstet Gynecol Sci.  2015 Nov;58(6):439-445. 10.5468/ogs.2015.58.6.439.

Comparison of the performance of screening test for gestational diabetes in singleton versus twin pregnancies

• Jung YJ
• Kwon JY
• Cho HY
• Park YW
• Kim YH

• KMID: 2314058
• DOI: http://doi.org/10.5468/ogs.2015.58.6.439

Abstract

OBJECTIVE
We compared the performance of the 50-g glucose challenge test (GCT) in singleton versus twin pregnancies and investigated the need for adjusting GCT cutoff values for gestational diabetes mellitus (GDM) in twin pregnancies among Korean women.
METHODS
A retrospective chart review was performed in women who underwent GCT at 24 to 28 weeks' gestation and delivered in our department between January 2000 and April 2008. GCT performance was compared between singleton and twin pregnancies for an ideal cutoff value of the GCT for GDM screening.
RESULTS
GCT results were available in 3,578 pregnancies (3,435 singleton and 143 twin pregnancies). The mean GCT value was higher in the twin group than in the singleton group. Women in the twin group had a higher mean GCT value (P=0.043) and a higher incidence of GCT > or =130, > or =135, and > or =140 mg/dL (P=0.014, 0.005, and 0.015, respectively). The false positive rate for GCT > or =140 mg/dL was significantly higher in the twin than in the singleton group (P=0.042). The optimal GCT screening cutoff value appears to be > or =145 mg/dL in twin pregnancies.
CONCLUSION
Our study demonstrates that the GCT is associated with a higher false positive rate in twin rather than singleton pregnancies. This study suggests we should consider adjusting the GCT cutoff value for GDM in Korean twin pregnancies.

Keyword

Diabetes, gestational; Pregnancy, twin; Screening test

MeSH Terms

Diabetes, Gestational*
Female
Glucose
Humans
Incidence
Mass Screening*
Pregnancy
Pregnancy, Twin*
Retrospective Studies
Twins*
Glucose

Figure

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  Fig. 1 Receiver operating characteristic curve for glucose challenge test in singleton pregnancies. This receiver operating characteristic shows the sensitivity and 1-specificity of diagnosis of gestational diabetes mellitus with singleton pregnancies undergoing glucose challenge test.

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  Fig. 2 Receiver operating characteristic curve for glucose challenge test in twin pregnancies. This receiver operating characteristic shows the sensitivity and 1-specificity of diagnosis of gestational diabetes mellitus for all patients with twin pregnancies undergoing glucose challenge test.

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