Nutr Res Pract.  2011 Feb;5(1):52-59.

Lifestyle, nutrient intake, iron status, and pregnancy outcome in pregnant women of advanced maternal age

• Bae HS

Abstract

The purpose of this study was to investigate how advanced maternal age influences lifestyle, nutrient intake, iron status, and pregnancy outcomes in pregnant women. The subjects of this study were 112 pregnant women who were receiving prenatal care at gynecologists located in Seoul. The subjects were divided into two groups according to their ages: those over age 35 were the advanced age group of pregnant women (AP) and those under age 35 were the young age group of pregnant women (YP). General factors, nutrient intakes, iron status, and pregnancy outcomes of the two groups were then compared. It was found that 72.5% of the YP group and 51.2% of the AP group had pre-pregnancy alcohol drinking experience; indicating that the YP group had more pre-pregnancy alcohol consumption than the AP group (P < 0.05). The only difference found in nutrient intake between the two groups was their niacin intakes which were 16.83 +/- 8.20 mg/day and 13.76 +/- 5.28 mg/day, respectively. When gestational age was shorter than 38.7 weeks, the average infant birth weight was 2.95 +/- 0.08 kg, and when gestational age was longer than 40 weeks, it averaged at about 3.42 +/- 0.08 kg. In other words, as gestational age increased, infant birth weight increased (P < 0.0001), and when maternal weight increased more than 15 kg, the infant birth weight increased significantly (P < 0.05). In conclusion, in order to secure healthy human resources, with respect to advanced aged women, it is necessary to intervene by promoting daily habits that consist of strategic increases in folate and calcium intake along with appropriate amounts of exercise.

Keyword

Advanced aged pregnancy; intake; lifestyle; pregnancy outcome

MeSH Terms

Aged
Alcohol Drinking
Birth Weight
Calcium
Female
Folic Acid
Gestational Age
Humans
Infant
Iron
Life Style
Maternal Age
Niacin
Pregnancy
Pregnancy Outcome
Pregnant Women
Prenatal Care
Calcium
Folic Acid
Iron
Niacin

Reference

1. Statistics Korea. Birth data in 2008 [Internet]. cited 2009 August 19. Available from: http//kostat.go.kr.

2. Hinz S, Rais-Bahrami S, Kempkensteffen C, Weiske WH, Schrader M, Magheli A. Fertility rates following vasectomy reversal: importance of age of the female partner. Urol Int. 2008. 81:416–420.

3. Khoshnood B, Bouvier-Colle MH, Leridon H, Blondel B. Impact of advanced maternal age on fecundity and women's and children's health. J Gynecol Obstet Biol Reprod (Paris). 2008. 37:733–747.

4. Kilic S, Yilmaz N, Zülfikaroglu E, Sarıkaya E, Kose K, Topcu O, Batioglu S. Obesity alters retrieved oocyte count and clinical pregnancy rates in high and poor responder women after in vitro fertilization. Arch Gynecol Obstet. 2010. 282:89–96.

5. Simchen MJ, Shulman A, Wiser A, Zilberberg E, Schiff E. The aged uterus: multifetal pregnancy outcome after ovum donation in older women. Hum Reprod. 2009. 24:2500–2503.

6. Usta IM, Nassar AH. Advanced maternal age. Part I: obstetric complications. Am J Perinatol. 2008. 25:521–534.

7. Salihu HM, Wilson RE, Alio AP, Kirby RS. Advanced maternal age and risk of antepartum and intrapartum stillbirth. J Obstet Gynaecol Res. 2008. 34:843–850.

8. Mbugua Gitau G, Liversedge H, Goffey D, Hawton A, Liversedge N, Taylor M. The influence of maternal age on the outcomes of pregnancies complicated by bleeding at less than 12 weeks. Acta Obstet Gynecol Scand. 2009. 88:116–118.

9. Altman AD, Bentley B, Murray S, Bentley JR. Maternal age-related rates of gestational trophoblastic disease. Obstet Gynecol. 2008. 112:244–250.

10. Kale A, Kuyumcuoğlu U, Güzel A. Is pregnancy over 45 with very high parity related with adverse maternal and fetal outcomes? Clin Exp Obstet Gynecol. 2009. 36:120–122.

11. Heo H, Hwang JY, Kim DG, Lee HJ, Sim JC, Yang HS. A clinical study of pregnancy and delivery in pregnant women 35 years and older. Korean J Obstet Gynecol. 2004. 47:458–463.

12. Yoon SJ, Chang BW, Kim HM, Kim SC, Son YS, Woo BH. A clinical study on the recent tendency of pregnancy and delivery in elderly gravida. Korean J Obstet Gynecol. 1996. 39:476–484.

13. Choi SR, Kim GJ, Lee SP, Kim SY, Yoon SJ, Lee ED. A clinical study of pregnancy and delivery in women aged 40 years and older. Korean J Obstet Gynecol. 2003. 46:612–616.

14. Park HJ, Lee SH, Cha DH, Kim IH, Jun HS, Lee KJ, Song SA, Park HR, Chung CJ, Lee CN. Pregnancy outcomes in women aged 35 and older. Korean J Obstet Gynecol. 2006. 49:2066–2074.

15. Choi JH, Han HJ, Hwang JH, Chung SR, Moon H, Park MI, Cha KJ, Choi HS, Oh JE, Park YS. Meta analysis of clinical studies of pregnancy and delivery in elderly gravida. Korean J Obstet Gynecol. 2006. 49:293–308.

16. Kil K, Lee GSR, Kwon JY, Park IY, Kim SJ, Shin JC, Kim SP. Impact of maternal age of 40 years or older on pregnancy outcomes. Korean J Perinatol. 2007. 18:125–130.

17. Kim TE, Lee SP, Park JM, Whang BC, Kim SY. The effects of maternal age on outcome of pregnancy in healthy elderly primipara. Korean J Perinatol. 2009. 20:146–152.

18. Sayal K, Heron J, Golding J, Alati R, Smith GD, Gray R, Emond A. Binge pattern of alcohol consumption during pregnancy and childhood mental health outcomes: longitudinal population-based study. Pediatrics. 2009. 123:e289–e296.

19. Yang Q, Wen SW, Phillips K, Oppenheimer L, Black D, Walker MC. Comparison of maternal risk factors between placental abruption and placenta previa. Am J Perinatol. 2009. 26:279–286.

20. The Korean Society of nutrition. Dietary reference intakes for Koreans. 2005. Seoul: The Korean Nutrition Society.

21. Black MM. Effects of vitamin B₁₂ and folate deficiency on brain development in children. Food Nutr Bull. 2008. 29:S126–S131.

22. Kim YJ, Lee SS. The relation of maternal stress with nutrients intake and pregnancy outcome in pregnant women. Korean J Nutr. 2008. 41:776–785.

23. Guelinckx I, Devlieger R, Mullie P, Vansant G. Effect of lifestyle intervention on dietary habits, physical activity, and gestational weight gain in obese pregnant women: a randomized controlled trial. Am J Clin Nutr. 2010. 91:373–380.

24. Jang HM, Ahn HS. Serum iron concentration of maternal and umbilical cord blood during pregnancy. Korean J Community Nutr. 2005. 10:860–868.

25. Pena-Rosas JP, Viteri FE. Effects of routine oral iron supplementation with or without folic acid for women during pregnancy. Cochrane Database Syst Rev. 2006. 3:CD004736.

26. Viteri FE, Berger J. Importance of pre-pregnancy and pregnancy iron status: can long-term weekly preventive iron and folic acid supplementation achieve desirable and safe status? Nutr Rev. 2005. 63:S65–S76.

27. Cogswell ME, Parvanta I, Ickes L, Yip R, Brittenham GM. Iron supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial. Am J Clin Nutr. 2003. 78:773–781.

28. Ward RJ, Wilmet S, Legssyer R, Crichton RR. Iron supplementation during pregnancy-a necessary or toxic supplement? Bioinorg Chem Appl. 2003. 1:169–176.

29. Rioux FM, LeBlanc CP. Iron supplementation during pregnancy: what are the risks and benefits of current practices? Appl Physiol Nutr Metab. 2007. 32:282–288.

30. Cole ZA, Gale CR, Javaid MK, Robinson SM, Law C, Boucher BJ, Crozier SR, Godfrey KM, Dennison EM, Cooper C. Maternal dietary patterns during pregnancy and childhood bone mass: a longitudinal study. J Bone Miner Res. 2009. 24:663–668.

31. Yu KH, Yoon JS. Comparison and Evaluation of Hematological Indices for Assessment of Iron Nutritional Status in Korean Pregnant Women(III). Korean J Nutr. 2000. 33:532–539.

32. Lee KS, Ferguson RM, Corpuz M, Gartner LM. Maternal age and incidence of low birth weight at term: a population study. Am J Obstet Gynecol. 1988. 158:84–89.