Nutr Res Pract.  2008 Sep;2(3):158-164.

Effects of cranberry powder on serum lipid profiles and biomarkers of oxidative stress in rats fed an atherogenic diet

• Kim MJ
• Jung HN
• Kim KN
• Kwak HK

Abstract

This study investigated that the antioxidative effect of freeze-dried cranberry powder against protein and lipid oxidation and ameliorative effect of serum lipid profile in rat fed atherogenic diet. Six weeks old male Sprague-Dawley rats were divided into the following four groups: normal diet group with 5% corn oil (control), atherogenic diet group with 5% corn oil, 10% lard, 1% cholesterol, and 0.5% sodium cholate (HFC), atherogenic plus 2% cranberry powder diet group (HFC + C2), and atherogenic plus 5% cranberry powder diet group (HFC + C5), and respective diet and water were fed daily for 6 weeks. After the experimental period, the serum lipid profile, such as total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride, ferric reducing ability of plasma (FRAP), plasma phenolics content, superoxide dismutase (SOD) activity, serum protein carbonyl and thiobarbituric acid reactive substances (TBARS) levels were examined. Total phenolic compound and total flavonoid levels in freeze-dried cranberry powder were 9.94 mg/g and 8.12 mg/g, respectively. Serum total cholesterol and LDL-cholesterol levels were not significantly different for cranberry powder treatment, but serum HDL-cholesterol level was significantly increased in HFC + C5 group compared with HFC group. Plasma FRAP value tended to be increased by cranberry powder treatment though there was no significant difference. Plasma total phenol concentrations and SOD activities were not significantly different among all groups. Serum protein carbonyl and TBARS levels were significantly decreased in HFC + C5 group compared with HFC group. Overall results suggested that freeze-dried cranberry powder might have the serum lipid improving effect, as well as antioxidative effect demonstrated by its protective effect against protein and lipid oxidation.

Keyword

Antherogenic diet; protein carbonyl; TBARS; FRAP; cranberry powder

MeSH Terms

Animals
Biomarkers
Cholesterol
Corn Oil
Diet
Diet, Atherogenic
Dietary Fats
Humans
Male
Oxidative Stress
Phenol
Plasma
Rats
Rats, Sprague-Dawley
Sodium Cholate
Superoxide Dismutase
Thiobarbiturates
Thiobarbituric Acid Reactive Substances
Vaccinium macrocarpon
Water
Cholesterol
Corn Oil
Dietary Fats
Phenol
Sodium Cholate
Superoxide Dismutase
Thiobarbiturates
Thiobarbituric Acid Reactive Substances
Water

Figure

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  Fig. 1 Change of body weights in rat. Values are mean.

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