Nucl Med Mol Imaging.  2011 Jun;45(2):87-92.

Development of 166Ho-phytate Complex for Radiosynovectomy

• Jalilian A
• Anvari A
• Bahrami-Samani A
• Mazidi M
• Ghannadi-Maragheh M

Abstract

BACKGROUND
66Ho-chloride was obtained by bombardment of natural Ho(NO3)3 dissolved in acidic media using thermal neutron flux (4-5x10(13) n.cm(-2).s(-1)).
METHODS
166Ho-holmium chloride (185 MBq) was used successfully for preparation of 166Ho-phytate complex with high radiochemical purity (>99.9 %, ITLC, MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to 2 days. The prepared complex solution (60 microCi/100 microl) was injected intraarticularly to male rat knee joints. Leakage of radioactivity from the injection site and its distribution in organs were investigated up to 2 days.
RESULTS
Approximately all of the injected dose had remained in the injection site 2 days after injection.
CONCLUSION
The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology.

Keyword

Phytate; Radiosynovectomy; Holmium-166; Biodistribution; SPECT

MeSH Terms

Acetic Acid
Animals
Humans
Knee Joint
Male
Neutrons
Phytic Acid
Radioactivity
Rats
Rheumatology
Tomography, Emission-Computed, Single-Photon
Viscosity
Acetic Acid
Phytic Acid