Neonatal Med.  2015 Aug;22(3):142-149. 10.5385/nm.2015.22.3.142.

The Usefulness of Birth Weight Z-Score as a Predictor of Catch Up Growth in Preterm Infants

Affiliations
  • 1Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea. choicw@snu.ac.kr
  • 2Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
  • 3Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
The aim of the study was to examine whether the degree of fetal smallness in small for gestational age (SGA) infants would increase the risk of catch-up-growth failure at 12 and 24 months corrected age (CA), and whether the high-calorie nutritional support would improve catch-up growth between 12 and 24 months CA.
METHODS
We conducted a retrospective cohort study on 103 preterm infants born between January 2010 and December 2011. Logistic regression analysis was performed to investigate whether the birth weight z-score would be an independent risk factor for catch-up growth failure at 12 or 24 months CA. Among the 46 infants with failed catch-up growth at 12 months CA, 16 infants were provided high-calorie nutritional support, including nutritional supplements and medium chain triglyceride (MCT) oil at the pediatric gastroenterology clinic.
RESULTS
Of 103 preterm infants, 34 infants (33%) were SGA and 69 infants (67%) were appropriate for gestational age (AGA). One birth weight z-score decrement increased the odds for catch-up growth failure 2.9 times at 12 months CA and 3.0 times at 24 months CA after adjustment for major neonatal morbidities. The increase in z-score between 12 and 24 months CA was significantly greater in the infants provided nutritional support than in the infants who were not provided nutritional support.
CONCLUSION
The birth weight z-score can be used as a predictor of catch-up growth failure. High-calorie nutritional support may improve weight gain during the second year in preterm infants with failed catch-up growth at 12 months CA.

Keyword

Small for gestational age; Preterm; Catch up growth; Z-score; High calorie nutritional support

MeSH Terms

Birth Weight*
Cohort Studies
Gastroenterology
Gestational Age
Humans
Infant
Infant, Newborn
Infant, Premature*
Logistic Models
Nutritional Support
Parturition*
Retrospective Studies
Risk Factors
Triglycerides
Weight Gain
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