Mycobiology.
2001 Sep;29(3):170-172.
Cytotoxicity of Paecilomyces tenuipes Against Human Carcinoma Cells, HepG2 and MCF-7 In Vitro
- Affiliations
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- 1Department of Biology, College of Natural Science, Dongguk University, Gyeongju 780-714, Korea. yhhan@dongguk.ac.kr
- 2Shin-Hwa Pharm. Research Inst., Sangin-Dong, Daegu 704-808, Korea.
Abstract
- The methanolic extract of fruiting body of Paecilomyces tenuipes DGUM 32001 showed significant cytotoxicity against human cancer cells: HepG2 and MCF-7. The methanolic extract was further fractionated with organic solvents such as chloroform and ethyl acetate in that order. Among the fractions tested, the ethyl acetate fraction showed the highest cytotoxicity against the carcinoma tested. The IC50 values of ethyl acetate fraction against HepG and MCF-7 were 40 and 9.6 microg/ml, respectively.
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