Lab Anim Res.  2010 Jun;26(2):165-171.

Prevalence of Laboratory Animal Allergy in Laboratory Workers

• Son TJ
• Bae JH
• Rhee CS
• Seong WK

Abstract

This study was designed to analyze the prevalence rates of laboratory animal allergy (LAA) in laboratory workers who perform researches with animals, and detect the mouse urinary allergen (Mus m 1) level in animal facilities for the purpose of establishing program for prevention of exposure to allergen. Study subjects were 240 employees who were working for two animal research institutions in Korea. Then the questionnaire and skin prick tests (SPTs) using twenty allergens were conducted with them. Presence of Mus m 1 in each air borne sample collected from animal facility was determined by using enzyme-linked immunosorbent assay. Through 240 questionnaire sheets, we found that; (1) 17.0% of workers in the direct exposure group answered that they had allergic symptoms due to laboratory animals; and (2) 6.2% of them had asthmatic symptoms. Twenty one subjects (27.6%) among the subjects with common allergens positive result and five subjects (6.6%) among the subjects with negative result showed a positive response to LAA under the SPTs. The Mus m 1 concentration (1.339 ng/m3) in the sample collected during cage exchange in mouse breeding room was up to 2.8 times higher than its concentration (0.483 ng/m3) in the sample collected at the stationary state. We suggest that LAA management programs including control of exposure to laboratory animal allergens should be considered as a measure to reduce the incidence of LAA and relieve the laboratory worker's allergic sensitivity to laboratory animals.

Keyword

Laboratory animal allergy; mus m 1; aero-allergen; exposure assessment

MeSH Terms

Allergens
Animal Experimentation
Animals
Animals, Laboratory
Breeding
Enzyme-Linked Immunosorbent Assay
Hypersensitivity
Incidence
Korea
Mice
Prevalence
Surveys and Questionnaires
Skin
Allergens

Figure

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  Figure 1. The positive rate of laboratory animal allergy in positive population to common allergen was 27.6% (21/76) and that of negative population to common allergen was 6.6% (5/ 76), respectively, showed with statistical significance (P<0.01).

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