Korean J Urol.  2009 Apr;50(4):408-412.

Basal Cell Carcinoma of the Prostate

• Kim YB
• Chung YG
• Joo HJ
• Lee WS
• Kim SJ
• Kim IH
• Im HW
• Kim SI
• Kim SJ

Abstract

Basal cell carcinoma (BCC) of the prostate, a rare variant of prostate cancer, is derived from the basal cells of prostatic ducts and acini. BCC generally occurs in elderly men with obstructive voiding symptoms and levels of serum prostate-specific antigen within the normal range. In most cases, diagnosis is made through transurethral resection or simple enucleation. Most cases are indolent, but local recurrence and metastasis have been reported in a few cases. Thus, radical surgery and long-term follow-up are recommended. We report a case of a 54-year-old man who underwent radical retropubic prostatectomy after being diagnosed with BCC during a transurethral resection performed for lower urinary tract symptoms. The patient has remained free of disease for 4 months after surgery.

Keyword

Prostate; Basal cell carcinoma; Transurethral resection of prostate; Prostatectomy

MeSH Terms

Aged
Carcinoma, Basal Cell
Follow-Up Studies
Humans
Lower Urinary Tract Symptoms
Male
Middle Aged
Neoplasm Metastasis
Prostate
Prostate-Specific Antigen
Prostatectomy
Prostatic Neoplasms
Recurrence
Reference Values
Transurethral Resection of Prostate
Prostate-Specific Antigen

Figure

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  Fig. 1 (A) The tumor cells showing tubular proliferation composed of atypical basal cells with intermingling cord of cells (H&E, ×100). Immunohistochemistry for basal cell markers p63 (B) and 34βE12 (C) showing the expression at the periphery of adenoid cyst-like nests and basal cell hyperplasia-like nests (×200).

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  Fig. 2 Endorectal magnetic resonance imaging (MRI) demonstrates a 3×2 cm mass lesion in the transition zone of the prostate. The mass shows a low signal intensity on T1-weighted image (A) and gadolinium-enhanced T1-weighted image (B) and intermediate signal intensity on T2-weighted image (C).

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  Fig. 3 (A) Bisected prostate demonstrates an ill-defined, whitish gray, solid, nodular growth of tumor located at the transition zone around the tissue defect caused by the previous transurethral resection. (B) Microscopic finding of the prostate showing the tumor composed of increased tubular structures that are confined to the transition zone (H&E, ×1).

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