Korean J Urol.  2009 Apr;50(4):404-407.

Prostatic Ductal Adenocarcinoma

• Jung H
• Lee HS
• Yoon SJ
• Kim KH

Abstract

Prostatic ductal adenocarcinoma is a rare neoplasm that develops from the prostatic urethra. We present an 85-year-old man with an exophytic lesion in the prostatic cavity, which was diagnosed after transurethral resection of the prostate. Histopathologically, the tumor was diagnosed as a ductal adenocarcinoma with endometrioid features and a Gleason score of 6.

Keyword

Adenocarcinoma; Prostate

MeSH Terms

Adenocarcinoma
Aged, 80 and over
Humans
Neoplasm Grading
Prostate
Urethra

Figure

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  Fig. 1 (A) Low-power view of the exophytic mass from the prostatic urethra showing a papillary architectural pattern (H&E, ×40). (B) High-power view showing papilla lined by tall columnar cells with hyperchromatic nuclei and prominent nucleoli (H&E, ×400).

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  Fig. 2 In the immunohistochemical examination, these cells showed focal prostate-specific antigen (PSA) positive immunoreactivity with anti-PSA antibody (×200).

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  Fig. 3 (A) T2-weighted axial magnetic resonance imaging (MRI) of the prostate using an endorectal coil showing the extracapsular extension at the right peripheral zone (arrow). (B) T2-weighted coronal MRI of the prostate showing diffuse, low signal intensity at both peripheral zones (arrows).

Reference

1. Millar EK, Sharma NK, Lessells AM. Ductal (endometrioid) adenocarcinoma of the prostate: a clinicopathological study of 16 cases. Histopathology. 1996. 29:11–19.

2. Elgamal AA, Van de Voorde W, Van Poppel H, Vandeursen H, Baert L, Lauweryns J. Exophytic papillary prostatic duct adenocarcinoma with endometrioid features, occurring in prostatic urethra after TURP. Urology. 1994. 43:737–742.

3. Kim DG, Seo YJ, Lee KS, Kim JR. Ductal adenocarcinoma of prostate. Korean J Urol. 2004. 45:742–745.

4. Bock BJ, Bostwick DG. Does prostatic ductal adenocarcinoma exist? Am J Surg Pathol. 1999. 23:781–785.

5. Dube VE, Farrow GM, Green LF. Prostatic adenocarcinoma of ductal origin. Cancer. 1973. 32:402–409.

6. Vera-Donoso CD, Vidal J, Gomez S, Garcia F, Gallego J, Llopis B, et al. Carcinoma of prostatic ducts. Eur Urol. 1991. 19:8–11.

7. Greene LF, Farrow GM, Ravits JM, Tomera FM. Prostatic adenocarcinoma of ductal origin. J Urol. 1979. 121:303–305.

8. Aydin F. Endometrioid adenocarcinoma of prostatic urethra presenting with anterior urethral implantation. Urology. 1993. 41:91–95.

9. Orihuela E, Green JM. Ductal prostate cancer: contemporary management and outcomes. Urol Oncol. 2008. 26:368–371.