Korean J Urol Oncol.  2015 Apr;13(1):29-34. 10.0000/kjuo.2015.13.1.29.

Symptom and Differences in Medication Adherence in Method of Administration of Tamsulosin, Finasteride Combination Therapy in Benign Prostatic Hyperplasia

• Kim KS
• Chung JH
• Kim TH
• Lee KS
• Lee SW

• KMID: 2307831
• DOI: http://doi.org/10.0000/kjuo.2015.13.1.29

Abstract

PURPOSE
It has been reported in several for factors on the drug compliance of patients, number of drug being taken, symptom, and pharmaceutical dosage form. However, Studies of drug compliance by dosing methodologies of tamsulosin, finasteride combination therapy and symptom relief for benign prostatic hyperplasia has not been performed. Therefore, we studied for symptom and differences in medication adherence in method of administration of tamsulosin, finasteride combination therapy.
MATERIALS AND METHODS
The groups were consisted in need of combination therapy of tamsulosin, finasteride on benign prostatic hyperplasia, one had packaged both drugs together (Group A, n=30) and the other were individually packaged both agents (Group B, n=30). International Prostatic Symptom Score (IPSS) were checked on first, 4weeks, and 8weeks. The evaluation was carried out of medicine compliance by checking the number of drugs 4weeks-interval. which was every 4weeks during 8weeks.
RESULTS
The properties other than the PSA in both groups, there was no statistically significant differences between patients. In first 4weeks, drug compliance of each Group A and B had tamsulosin 82.6%, 93.3% (p=0.033), finasteride 80.1%, 93.3% (p=0.042), and last 4weeks tamsulosin 80.6%, 93.7% (p=0.013), finasteride 79.5%, 93.7% (p=0.002) were checked. Group C, D had 81.4%, 96.4% (p=0.021) on 4weeks, 80.6%, 97.2% (p=0.011) on 8weeks.
CONCLUSIONS
For co-administration of finasteride and tamsulosin are required in patients with benign prostatic hyperplasia, in order to enhance drug compliance, both tablets have to prescript together in one package to be taken at one time is useful.

Keyword

Prostatic hyperplasia; Compliance; Tamsulosin; Finasteride

MeSH Terms

Compliance
Dosage Forms
Finasteride*
Humans
Medication Adherence*
Prostatic Hyperplasia*
Tablets
Dosage Forms
Finasteride
Tablets