Korean J Neurogastroenterol Motil.
2007 Dec;13(2):123-131.
Optimal Frequency of Sacral Electrical Stimulation to Promote Bowel Emptying in Spinal Cord Injured Rats
- Affiliations
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- 1Department of Internal Medicine and Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, Korea.
- 2Department of Rehabilitation Medicine, Wonkwang University School of Medicine, Iksan, Korea.
- 3Department of Surgery, Wonkwang University School of Medicine, Iksan, Korea.
- 4Department of Physiology and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea. lmy6774@wku.ac.kr
Abstract
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BACKGROUND/AIMS: The sacral nerve electrical stimulation (ES) has been used to promote bowel emptying in the spinal cord injured patients. However, optimal parameter of ES to promote bowel emptying was not established yet. The aim of this study was to investigate the effectiveness of ES to promote bowel emptying at spinal injured rats and find the optimal frequency.
METHODS
Thirty-one adult Sprague-Dawley female rats were used. A complete spinal cord transection was performed surgically at the T10 cord level. The electrodes for ES were implanted in the sacral spinal cord region. Intensity of stimulation was determined by the half of the movement threshold. Stimulation width was 0.3 ms. The frequencies of ES were 10 Hz, 30 Hz, and 50 Hz, for each group. ES was applied for 4 hours per day. We measured the body weight as well as the number and the weight of fecal pellet every morning.
RESULTS
The stool output was significantly higher in the group of 30 Hz stimulation than all other groups.
CONCLUSIONS
These results suggest that electrical stimulation could be used to promote bowel emptying in spinal cord injured patients and it is important to use an optimal frequency of stimulation for best improvement of bowel symptoms.
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