Korean J Nephrol.  2009 Nov;28(6):697-703.

A Case of Post-transplant Lymphoproliferative Disorder Manifested as Native Kidney Mass

• Yu JY
• Park MY
• Jeong YO
• Lee HK
• Park JC
• Lee SJ
• Chang YK
• Park SY
• Kim SY

Abstract

Post-transplant lymphoproliferative disorder (PTLD) following solid organ transplantation is an important form of post-transplant malignancy. PTLD is typically associated with Epstein-Barr virus (EBV) and occurs in the setting of immunosuppression resulting in a deficiency of EBV-specific cytotoxic T lymphocytes. PTLD encompasses heterogeneous lymphoproliferative diseases, from polyclonal proliferation resembling infectious mononucleosis to aggressive monomorphic proliferation such as diffuse large B-cell lymphoma. Clinically, PTLD is usually manifested as lymph nodal mass or extranodal mass of solid organs such as liver, transplanted kidney, tonsil, bone marrow or spleen. The authors experienced very rare case of PTLD manifested as a single mass in a native kidney. According to a review of the literature, this is a rare case of PTLD which developed in a native kidney after kidney transplantation. Initially under the impression of renal cell carcinoma, unilateral nephrectomy of the native kidney had performed, and after confirmed as PTLD by histologic diagnosis the patient had treated with reduction of immunosuppressants and chemotheraphy for PTLD, and eventually has got in complete remission.

Keyword

Lymphoproliferative disorder; Kidney transplantation

MeSH Terms

Bone Marrow
Carcinoma, Renal Cell
Herpesvirus 4, Human
Humans
Immunosuppression
Immunosuppressive Agents
Infectious Mononucleosis
Kidney
Kidney Transplantation
Liver
Lymphoma, B-Cell
Lymphoproliferative Disorders
Nephrectomy
Organ Transplantation
Palatine Tonsil
Spleen
T-Lymphocytes, Cytotoxic
Transplants
Immunosuppressive Agents