Korean J Med.  1997 Feb;52(2):253-256.

A Case of T Cell Chronic Lymphocytic Leukemia Associated with Pure Red Cell Aplasia

• Park SS
• Lee H
• Jang JH
• Song HM
• Lee SJ
• Kwak JY
• Yim CY
• Choi BM
• Cho YG
• Lee MK
• Kim YJ
• Lee HS
• Choi SI

Abstract

Pure red cell aplasia(PRCA) is characterized by anemia, absence of reticulocytes in the peripherial blood and selective erythroid hypoplasia in the bone marrow. Acquired PRCA is often associated with thymoma but may also occur in many diverse conditions, such as chromic lymphocytic leukemia, systemic lupus erythematosus, autoimmune disorders, T gamma lymphocytosis, acquired hypogammaglobulinemia, acquired immunodeficiency syndrome. Recently we experienced a case of T cell chronic lymphocytic leukemia associated with pure red cell aplasia. A 65-year-old man was presented with severe anemia. absolute reticulocytopenia, hepatosplenomegaly and lymphocytosis(T cell marker' CD2, CD7 positive). Bone marrow findings showed a marked decrease in erythroid precursors and normal maturations of granulocytic and megakaryocytic series, which were consistent with pure red cell aplasia. So we report this case with a review of the literature.

Keyword

Pure red cell aplasia; Chronic lymphocytic leukemia; T lymphocyte

MeSH Terms

Acquired Immunodeficiency Syndrome
Aged
Anemia
Bone Marrow
Common Variable Immunodeficiency
Humans
Leukemia, Lymphocytic, Chronic, B-Cell*
Leukemia, Lymphoid
Lupus Erythematosus, Systemic
Lymphocytosis
Red-Cell Aplasia, Pure*
Reticulocytes
Thymoma