Korean J Med.  2000 Feb;58(2):227-233.

A case of acromegaly associated with moyamoya disease, coronary arterial stenosis, and dilated cardiomyopathy

• Lee DH
• Kim YJ
• Lee DB
• Park JH
• Chung DJ
• Chung MY
• Lee TH

Abstract

A 19-year-old girl with typical features of acromegaly, duration of which was thought to be above 10 years, presented with dyspnea. After serial studies, dilated cardiomyopathy and critical stenosis of left anterior descending coronary artery were demonstrated. Brain MRI revealed the following changes: the pituitary gland was enlarged and its upper margin was upwardly convex; severe cerebral atrophy and multiple signs of vascular abnormalities were present. Cerebral angiographic studies demonstrated the presence of complete occlusion of left carotid artery and severe stenosis of right carotid artery with the formation of collateral networks of vessels. The patient was thus diagnosed as having moyamoya disease that was thought to be congenital according to her past histories. Her cardiac function was slightly improved after percutaneous transluminal coronary angioplasty. Operation for the pituitary lesion and moyamoya disease was not performed due to poor general condition, but serum growth hormone concentration was adequately suppressed after octreotide therapy. We consider that this is a very rare case of acromegaly associated with moyamoya disease, coronary arterial disease and dilated cardiomyopathy.

Keyword

Pituitary gigantism; Moyamoya disease; Coronary artery disease; And dilated cardiomyopathy

MeSH Terms

Acromegaly*
Angioplasty, Balloon, Coronary
Atrophy
Brain
Cardiomyopathy, Dilated*
Carotid Arteries
Constriction, Pathologic*
Coronary Artery Disease
Coronary Vessels
Dyspnea
Female
Gigantism
Growth Hormone
Humans
Magnetic Resonance Imaging
Moyamoya Disease*
Octreotide
Pituitary Gland
Young Adult
Growth Hormone
Octreotide