Korean J Med.  2000 Jul;59(1):91-94.

A case of clonorchiasis with peripheral eosinophilia and marked infiltration of eosinophils in the liver

• Lee KA
• Kim HR

Abstract

A marked accumulation of eosinophils occurs in several disorders, such as allergic diseases, parasitic infections, and cancers. Recently we experienced a case of clonorchiasis with a presentation of peripheral eosinophilia and eosinophilic infiltration in the liver. A 46-year-old man was admitted to the hospital because of epigastric pain. The white boold cell count was 33,900/mm3 with 70% eosinophils. Two stool examinations were negative for parasite eggs. Skin test gave a positive test for Clonorchis sinensis. CT showed inhomogeneous enhancement with multiple subcapsular low attenuation in the liver. The pathological features of the liver, which were characterized by marked infiltration of eosinophils in the periportal and intralobular areas and no evidence of parasitic ova, granuloma, or tumor, suggested that the lesions were caused by the hypereosinophilic syndrome. He was treated with corticosteroids. During management, however, antibody against C. sinensis in serum using micro-ELISA was positive and a stool specimen gave a positive test for C. sinensis ova. We diagnosed clornorchiasis and administered praziquantel to him. Peripheral eosinophilia has improved.

Keyword

Angioplasty; Stents; Arteries

MeSH Terms

Adrenal Cortex Hormones
Angioplasty
Arteries
Cell Count
Clonorchiasis*
Clonorchis sinensis
Eggs
Eosinophilia*
Eosinophils*
Granuloma
Humans
Hypereosinophilic Syndrome
Liver*
Middle Aged
Ovum
Parasites
Parasitic Diseases
Praziquantel
Skin Tests
Stents
Adrenal Cortex Hormones
Praziquantel