Korean J Med.  2006 May;70(5):586-590.

A case of Stevens-Johnson syndrome caused by oxcarbazepine

• Ryu DR
• Song PS
• Lee JY
• Rhee JY
• Oh MJ
• Lee BJ
• Choi DC

Abstract

Stevens-Johnson syndrome and toxic epidermal necrolysis are acute life-threatening conditions. Aromatic antiepileptic drugs such as carbamazepine, phenytoin and phenobarbital are frequently associated with severe adverse cutaneous reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Oxcarbazepine, a 10-keto derivative of carbamazepine has been reported to have a similar range of efficacy and fewer side effects than carbamazepine because it is a prodrug of a monohydroxy derivative. Because there are few clinical records of oxcarbazepine induced erythemamultiforme-like skin eruptsions, we reported a case of Stevens-Johnson syndrome thought to be caused by the use of oxcarbazepine in a 66-year-old male. Diffuse erythematous maculopapular eruptions were developed on his whole body 30 days after beginning with oxcarbazepine. The clinical and histologic findings of the patient were compatible with Stevens-Johnson syndrome. Although it is rare, oxcarbazepine can cause severe adverse cutaneous reactions.

Keyword

Oxcarbazepine; Stevens-Johnson syndrome

MeSH Terms

Aged
Anticonvulsants
Carbamazepine
Humans
Male
Phenobarbital
Phenytoin
Skin
Stevens-Johnson Syndrome*
Anticonvulsants
Carbamazepine
Phenobarbital
Phenytoin