Changes of the serum and dialysate leptin in continuous ambulatory peritoneal dialysis patients with time

Park, Jong Won; Do, Jun Young

Abstract

BACKGROUND: The aim of this study was to investigate the changes of fat mass and the serum and dialysate leptin among CAPD patients with time.
METHODS
52 patients were enrolled. The S- and D-leptin and BIA were measured at the 2nd week and the 12th month after initiation of PD.
RESULTS
1) There were significant increases in fat mass, but significant decreases in the ECF% and lean body mass at the 12th month after initiation of PD (p<0.01, respectively). 2) There were significant increases in the S-leptin, D-leptin and D-VEGF at the 12th month after initiation of PD (p<0.00, respectively). 3) There were significant increases in the fat mass, S-leptin and D-leptin at the 12th month after initiation of PD in both males and females, according to the gender (p<0.05, respectively). According to the etiology, there were significant increases in the fat mass, S-leptin and D-leptin in the diabetic patients (p<0.001, respectively). 4) Factors associated with the changes of fat mass during the first 1 year were nPCR, D/P 4hr Cr, glucose absorption via the peritoneal cavity and the duration of dialysis (p<0.05, respectively). 5) Factors associated with the changes of S-leptin during the first 1 year were diabetes, % fat mass and the hs-CRP (p=0.05, respectively). Factors associated with the changes of D-leptin were D/P4 Cr, % fat mass and the S-leptin (p<0.05, respectively) 6) Factors associated with the changes of D/S leptin during the first 1 year were D/P 4hr Cr, % fat mass, hs-CRP, the duration of dialysis and the D-VEGF (p<0.05, respectively) 7) There were significant correlations between delta D-VEGF and delta D/S leptin during the 1st year.
CONCLUSIONS
Increased leptin levels of serum and dialysate might be associated with the fat mass in PD patients with time.