Korean J Helicobacter Up Gastrointest Res.  2014 Mar;14(1):13-17. 10.7704/kjhugr.2014.14.1.13.

Pharmacological Therapy of Peptic Ulcer

• Oh JH

• KMID: 2305149
• DOI: http://doi.org/10.7704/kjhugr.2014.14.1.13

Abstract

Peptic ulcer disease is one of the most commonly encountered diseases. Despite the decrease of Helicobacter pylori infection, the use of aspirin and non-steroidal anti-inflammatory drugs has increased in recent years. Peptic ulcer bleeding is a common emergency associated with high mortality. As an adjunct to endoscopic treatment, acid suppression with proton pump inhibitors (PPIs) is important in the management of peptic ulcer bleeding. A high dose intravenous PPI is effective in reducing rebleeding and the need for surgery. However, data about non-high dose intravenous PPIs are limited. In addition, novel PPIs are focused in this review, since progress has been made regarding new PPIs.

Keyword

Peptic ulcer; Peptic ulcer hemorrhage; Proton pump inhibitors; Therapy

MeSH Terms

Aspirin
Emergencies
Helicobacter pylori
Hemorrhage
Mortality
Peptic Ulcer Hemorrhage
Peptic Ulcer*
Proton Pump Inhibitors
Aspirin
Proton Pump Inhibitors