Clinicopathologic Features and Prognosis in Peripheral Cholangiocarcinoma

Kim, Ho Young; Choi, Chang Soo; Choi, Young Kil

Abstract

BACKGROUND/AIMS: There have been few reports about surgical treatment for peripheral cholangiocar inoma. The aim of this review was to analyze the clinicopathologic features of peripheral cholangio carcinoma and the results of treatment.
METHODS
Between 1989 and 1996, 34 patients underwen surgical exploration for peripheral cholangiocarcinoma of liver and were completely followed up.
RESULTS
Twenty one patients underwent hepatic resection (61.8%). The morbidity was 35.3% (12 patients) There was no death due to operation. In the patients who had received hepatic resection, the 1-, 3 and 5- year survival rates were 38.5%, 32.1% and 32.1%, respectively. Mean survival time of non resection group was 4.2 months (from 1.0 month to 9.0 months). The patients with curative resection (p=0.02) and those with negative lymph nodes metastasis (p=0.02) had a better survival. The size gross appearence, histologic grade, lymphatic invasion and perineural invasion of tumor were shown to have no influence on survival.
CONCLUSIONS
Surgical resection improves survival rate with accepta ble morbidity and mortality. To obtain better results, curative resection with negative resection margin and complete lymph node dissection is recommended.