Korean J Pathol.  1998 Mar;32(3):222-225.

Intraductal Variant of Peripheral Cholangiocarcinoma of the Liver A report of three cases

• Lee WM
• Jeon SH
• Hong EK
• Park MH
• Lee JD

Abstract

Intraductal variant of peripheral cholangiocarcinoma is extremely rare. This variant shows intraductal growth and intraluminal extension without any infiltrative growth. The mode of intraductal growth is not known. The prognosis of this variant is better than that of usual cholangiocarcinoma. We report three cases, one of which is associated with Clonorchis sinensis (CS) infection. The tumors were entirely confined within the dilated peripheral tributaries of the intrahepatic bile duct. Microscopically, the tumors were well to moderately well differentiated, with a papillary or a micropapillary growth pattern. Focal clear cytoplasmic change and mucin production were noted. The tumors showed intraductal spreading without any invasion to the liver parenchyme. Mucosal hyperplasia and dysplasia were noted in the adjacent ducts. The authors assume that intraductal cholangiocarcinoma is a distinct subtype, and persistent irritation, such as, CS infection may undergo a malignant transformation through mucosal dysplasia.

Keyword

Intraductal variant; Peripheral cholangiocarcinoma; Clonorchis sinensis; Liver

MeSH Terms

Bile Ducts, Intrahepatic
Cholangiocarcinoma*
Clonorchis sinensis
Cytoplasm
Hyperplasia
Liver*
Mucins
Prognosis
Mucins