Korean J Fam Med.  2013 Nov;34(6):420-428. 10.4082/kjfm.2013.34.6.420.

The Association between Oxidative Stress and Metabolic Syndrome in Adults

• Chung SW
• Kang SG
• Rho JS
• Kim HN
• Song IS
• Lee YA
• Heo SJ
• Song SW

• KMID: 2304168
• DOI: http://doi.org/10.4082/kjfm.2013.34.6.420

Abstract

BACKGROUND
In this Study, we investigated the effects of lifestyle and metabolic syndrome on free oxygen radical levels in men and women in Korea.
METHODS
A total of 254 adults were included in this study from February 2011 to June 2012 at a health promotion center. Information of the lifestyles and presence of metabolic syndrome factors was obtained. Biochemical markers were measured and free oxygen radicals test (FORT) was performed on the blood.
RESULTS
Of the 254 subjects, 86 (33.9%) had metabolic syndrome, and 187 (73.6%) were men. Between the subjects with and without metabolic syndrome, there was a significant increase in alanine aminotransferase and serum FORT values in the subjects with metabolic syndrome. Multiple linear regression analysis showed that high-sensitivity C-reactive protein (hs-CRP) (P = 0.004), metabolic syndrome (P = 0.037), and female gender (P = 0.030) were independent predictors of serum FORT values. The subjects with high fasting blood sugar level or low high density lipoprotein cholesterol levels showed high serum FORT values.
CONCLUSION
High hs-CRP, the presence of metabolic syndrome, and female gender were associated with the high oxidative stress. High oxidative stress was associated with the presence of metabolic syndrome.

Keyword

Metabolic Syndrome; Reactive Oxygen Species; Oxidative Stress; High-Sensitivity C-reactive Protein

MeSH Terms

Adult*
Alanine Transaminase
Biomarkers
Blood Glucose
C-Reactive Protein
Cholesterol
Cholesterol, HDL
Fasting
Female
Health Promotion
Humans
Life Style
Linear Models
Lipoproteins
Male
Oxidative Stress*
Oxygen
Reactive Oxygen Species
Alanine Transaminase
Blood Glucose
C-Reactive Protein
Cholesterol
Cholesterol, HDL
Lipoproteins
Oxygen
Reactive Oxygen Species