Korean J Fam Med.
2014 Nov;35(6):276-282. 10.4082/kjfm.2014.35.6.276.
Association between Apolipoprotein E Polymorphism and Chronic Kidney Disease in the Korean General Population: Dong-gu Study
- Affiliations
-
- 1Department of Preventive Medicine, Chosun University School of Medicine, Gwangju, Korea.
- 2Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea. mhshinx@paran.com
- 3Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, Korea.
- 4Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan, Korea.
- 5Department of Preventive Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
- 6Department of Neurology & Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Institute of Chonbuk National University Hospital, Jeonju, Korea.
- 7Department of Preventive Medicine, Seonam University College of Medicine, Namwon
- 8Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, Korea.
- KMID: 2304138
- DOI: http://doi.org/10.4082/kjfm.2014.35.6.276
Abstract
- BACKGROUND
Few studies have investigated the association between Apolipoprotein E (APOE) polymorphisms and chronic kidney disease (CKD) in the general population, and their results are inconsistent.
METHODS
The current study population was composed of 9,033 subjects aged > or = 50 years who participated in the baseline survey of the Dong-gu Study, which was conducted in Korea between 2007 and 2010. APOE polymorphisms were identified by polymerase chain reaction, and the estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease equation.
RESULTS
Individuals with the APOE E2 allele had significantly lower total and low density lipoprotein cholesterol levels, those with the APOE E4 allele had lower high density lipoprotein (HDL) cholesterol levels, and those with the APOE E3 allele had lower log-triglyceride levels. Adjusting for covariates (sex, age, body mass index, smoking, systolic blood pressure, hypertension, diabetes, total cholesterol, HDL cholesterol, log-transformed triglycerides, and log-transformed albumin to creatinine ratio), mean eGFR was not significantly different among APOE alleles (E2, 69.4 mL/min/1.73 m2; E3, 69.5 mL/min/1.73 m2; E4, 69.4 ml/min/1.73 m2; P = 0.873). Additionally, the odds ratios (ORs) indicated that APOE polymorphisms were not independent risk factors for CKD (OR, 1.07; 95% confidence interval [CI], 0.91 to 1.26 for the E2 vs. E3 allele; OR, 1.01; 95% CI, 0.88 to 1.16 for the E4 vs. E3 allele).
CONCLUSION
APOE polymorphisms were not associated with either eGFR or CKD in the general Korean population.
MeSH Terms
-
Alleles
Apolipoproteins E
Apolipoproteins*
Blood Pressure
Body Mass Index
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Creatinine
Surveys and Questionnaires
Diet
Glomerular Filtration Rate
Hypertension
Korea
Lipoproteins
Odds Ratio
Polymerase Chain Reaction
Polymorphism, Genetic
Renal Insufficiency, Chronic*
Risk Factors
Smoke
Smoking
Triglycerides
Apolipoproteins
Apolipoproteins E
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Creatinine
Lipoproteins
Smoke
Triglycerides
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