Korean J Epidemiol.  2008 Dec;30(2):272-280.

Characteristics of major depressive disorder according to family history of depression : A CRESCEND-K (Clinical Research Center for Depression in Korea) study

• Jeong S
• Yim HW
• Jung Y
• Jo S
• Jun T
• Jung SW
• Lee M
• Kim J

Abstract

PURPOSE
People with a family history of mood disorder are more likely to have depression. This study compared the characteristics of non-psychotic major depression disorder according to family history of depression. METHOD: Subjects were total of 817 persons recruited for the CRESCEND-K multicenter trial. Characteristics of depression and suicide history of patients with and without a family history of depression were assessed. Family history was determined through self-report.
RESULTS
Of 817 participants, 12.4% had a positive family history of depression. Those with family history of depression reported an earlier age at onset of MDD, and more psychiatric comorbidity. Severity of depression and anxiety were not different according to family history of depression. There were no difference in attempted suicide history, number of attempted suicide and age at onset of 1st attempted suicide according to such a family history.
CONCLUSION
Patients with family history of depression reported earlier onset of MDD and more history of psychiatric comorbidity.

Keyword

Major depressive disorder; Family history

MeSH Terms

Anxiety
Comorbidity
Depression
Depressive Disorder, Major
Humans
Mood Disorders
Suicide
Suicide, Attempted