Korean J Dermatol.  1998 Aug;36(4):688-693.

A Case of CD3O-negative Large T-Cell Lymphoma Showing p53 and mdm-2 Expression

• Kang SG
• Ro YS
• Park CK

Abstract

Primary cutaneous large cell lymphomas of the T-cell phenotype are relatively uncommon. Previous studies have revealed the following prognostic variables: the distribution of skin lesions, a history of pre-existing mycosis fungoides, CD30(Ki-1) antigen positivity and anaplastic morphology. CD30 antigen positivity has been associated with an indolent clinical course, in contrast to CD30-negative cases. However, a recent study revealed that multicentric skin lesions confer a worse prognosis on this subgroup of patients rather than the absence of CD30 antigen. p53 immunoreactivity also has been reported to be associated with high grade non-Hodgkin's lymphoma, although it is relatively uncommon. Herein, we report a case of a patient with EBV-related, CD30-negative primary cutaneous large cell lymphoma of the T-cell phenotype showing p53 and mdm-2 expression. She was initially diagnosed as having a benign-looking deep folliculitis or furunculosis, but treated successfully with radiation therapy without recurrence up to now.

Keyword

CD30(Ki-1)-negative; Large cell lymphoma; p53; mdm-2

MeSH Terms

Antigens, CD30
Folliculitis
Furunculosis
Humans
Lymphoma
Lymphoma, Non-Hodgkin
Lymphoma, T-Cell*
Mycosis Fungoides
Phenotype
Prognosis
Recurrence
Skin
T-Lymphocytes*
Antigens, CD30