Korean J Dermatol.
2000 Aug;38(8):1133-1135.
A Case of Coumarin-Induced Skin Necrosis
- Affiliations
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- 1Department of Dermatology, College of Medicine, The Catholoic University of Korea, Seoul, Korea.
Abstract
- Coumarin-induced skin necrosis is a rare complication of oral administration of coumarin derivatives. Clinically, the lesions begin with well-defined purpuric patches and progress to bullae and necrosis on the trunk, buttock or female breast. Histopathologic findings show a fibrinoid degeneration or thrombus formation in the dermal blood vessels with occasional vessel rupture and hemorrhage. We report a 77-year-old man who suffered from a typical necrotic patch on his right buttock developing during the course of coumarin therapy. Our case was diagnosed as coumarin-induced skin necrosis, based on the characteristic clinical course and histopathologic findings.
