Korean J Dermatol.  2005 Mar;43(3):425-427.

A Case of Dariers Disease Treated with Adapalene

• Hwang ES
• Kim YJ
• Yu DS
• Song HJ
• Oh CH

Abstract

Dariers disease is inherited as an autosomal dominant trait and characterized by follicular pruritic hyperkeratotic papules. The onset is usually in late childhood and the course of the disease is chronic and slowly progressive in most cases. Dariers disease is refractory to treatment with most conventional keratolytics and anti-inflammatory agents. To date, oral and topical retinoid products have been the mainstay therapy for this population, but local as well as systemic side effects often limit their effectiveness. We present a case of localized Dariers disease which responded promptly to the topical application of adapalene 0.1% gel without side effects. A review of treatment for Dariers disease also is presented.

Keyword

Dariers disease; Adapalene

MeSH Terms

Anti-Inflammatory Agents
Darier Disease*
Adapalene
Anti-Inflammatory Agents