Twice-per-week Application of an Adapalene-benzoyl Peroxide Fixed-dose Combination Gel as Maintenance Treatment for Acne Vulgaris in Adults

Seol, Jung Eun; Lee, Wonkyung; Kang, Jung Nan; Kim, Hyojin

Abstract

BACKGROUND
The efficacy and safety of daily maintenance treatment with an adapalene-benzoyl peroxide (adapalene-BPO) fixed-dose combination gel is established in acne vulgaris in adults.
OBJECTIVE
This study evaluated the efficacy and tolerability of twice-per-week maintenance therapy with an adapalene-BPO combination gel for acne vulgaris in adults.
METHODS
All patients applied the adapalene-BPO combination gel once daily during the initial 8 weeks. Subsequently, the patients were randomized into two groups. The maintenance group applied the ointment twice-per-week for 12 weeks of maintenance treatment, while the control group discontinued treatment after the initial 8 weeks active treatment. The changes in the mean numbers of total, inflammatory, and non-inflammatory lesions were assessed.
RESULTS
During maintenance treatment, the changes in the average numbers of total and inflammatory lesions in the maintenance group differed significantly from the control group.
CONCLUSION
Twice-per-week application of an adapalene-BPO combination gel after active treatment appears to be a good option for the maintenance therapy of acne vulgaris in adults.