Korean J Dermatol.
2010 Aug;48(8):665-671.
Clinical Efficacy and Tolerance of 1% Nadifloxacin Cream in the Treatment of Mild to Moderate Acne Vulgaris in South Korea
- Affiliations
-
- 1Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea. romio@hanyang.ac.kr
- 2Department of Dermatology, Hallym University College of Medicine, Seoul, Korea.
- 3Department of Dermatology, Kyunghee University College of Medicine, Seoul, Korea.
- 4Department of Dermatology, Korea University College of Medicine, Seoul, Korea.
- 5Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
- 6Department of Dermatology, Sungkyunkwan University College of Medicine, Seoul, Korea.
- 7Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
- 8Department of Dermatology, Ajou University College of Medicine, Seoul, Korea.
- 9Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
Abstract
- BACKGROUND
Antimicrobials have been a mainstay of inflammatory acne treatment for more than 30 years. However, antibiotic-resistant propionibacteria had been isolated with increased frequency, and associated with failure to respond to antibiotic therapy.
OBJECTIVE
The aim of this study was to investigate the clinical efficacy and tolerance of 1% nadifloxacin cream.
METHODS
In the final analysis, 197 patients with mild to moderate facial acne vulgaris were enrolled. The patients were instructed to apply 1% nadifloxacin cream twice daily to the affected skin after washing the face. Following 2 and 4 weeks of treatment, patients were observed for clinical response: number of the acne lesions, Korea acne grading system (KAGS), global improvement, and occurrence of adverse reactions.
RESULTS
During 4 weeks of treatment, nadifloxacin caused significant reduction in the number of inflamed papulo-pustular lesions and open/closed comedones. In addition, significant reduction of KAGS was observed. About 96% of patients showed clinical improvement in the overall evaluation of the therapeutic effect by physicians. All reported adverse events were mild.
CONCLUSION
This study shows that 1% nadifloxacin cream can be an effective and safe treatment for mild to moderate acne vulgaris.
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