Korean J Dermatol.
2012 Mar;50(3):262-265.
Five Cases of Onychatrophy Following Bleomycin Intralesional Injections for Periungual Warts
- Affiliations
-
- 1Department of Dermatology, Pusan National University School of Medicine, and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea. smargie@hanmail.net
Abstract
- Onychatrophy is the processes in which the nail has initially formed satisfactorily and then shows total or partial regression. The causes of onychatrophy with pterygium include lichen planus, acrosclerosis, Stevens-Johnson syndrome, and cicatrical pemphigoid, and those without pterygium include severe paronychia, Stevens-Johnson syndrome, epidermolysis bullosa, and drugs. Bleomycin is an antitumor, antibacterial, and antiviral agent used in many dermatologic diseases such as warts, vascular anomalies, hemangioma, and cutaneous malignancies. Cutaneous adverse effects of bleomycin strongly depend on the route of administration and dosage. Bleomycin intralesional injection for periungual warts could result in permanent Raynaud phenomenon, nail dystrophy, and nail loss. We report five cases of onychatrophy following bleomycin intralesional injections for periungual warts. We remind that if bleomycin intralesional injection near the nail matrix is inevitable in recalcitrant periungual warts, the performer must manipulate precisely to avoid adverse effects.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Study of Pulsed Dye Laser Followed by Intralesional Bleomycin Treatment Compared to Lone Intralesional Bleomycin Treatment for Recalcitrant Periungual Warts
- Intralesional Bleomycin injection for the treatment of Warts
- Therapeutic Evaluation for Intralesional Injection of Bleomycin Hydrochloride in Warts
- Treatment of Periungual Warts with Bleomycin Pricking
- Intralesional Bleomycin Therapy Using a Lancet in the Treatment of Recalcitrant Warts
