Korean J Community Nutr.  2001 Feb;6(1):69-75.

Effects of Isoflavone Supplementation on Serum Lipids in Hyperlipidemic Postmenopausal Women

• Lee DH
• Sung CJ
• Lee HS
• Kim MH
• Seo YL

Abstract

Intake of soy protein the fisk factors associated with cardiovascular disease in postmenopausal women. This study was designed to effects of isoflavone supplementation on serum lipids in 16 hyperlipidemic postmenopausal women . For this purpose, an intervention study was conducted for 12 weeks. Subjects were healthy, free-living women consuming habitual diets with 0.3g/d of isoflavone. Food and nutrient intake was obtained by 24-hr recall method and anthropometric measurement were made. Systolic and diastolic blood pressure, total serum cholesterol. HDL-cholesterol and LDL-cholesterol were determined before and after the isoflavone supplementation. The results were summarized as follows. The average age, hight, weight and BMI of the subject were 65.3 years, 151.4 cm, 62.2 kg and 27.1, respectively. The systolic blood pressure and diastolic blood pressure were not reduced significantly with isoflavone supplementation. Total cholesterol (p<0.001), HDL-C(p<0.05), and LDL-C(p<0.01) were significantly increased after isoflavone concentration. In conclusion, isoflavone supplementation was not effective to modify risk factors for cardiovascular disease.

Keyword

isoflavone supplementation; serum lipids; hyperlipidemia; high density lipoprotein cholesterol; low density lipoprotein cholesterol

MeSH Terms

Blood Pressure
Cardiovascular Diseases
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Diet
Female
Humans
Hyperlipidemias
Clinical Trial
Risk Factors
Soybean Proteins
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Soybean Proteins