Korean J Biol Psychiatry.
2005 Nov;12(2):196-206.
Acute Alcohol Responses and Personality Traits by Aldehyde Dehydrogenase 2 Genotype Variances in Patients with Alcohol Dependence
- Affiliations
-
- 1Seoul National Hospital, Seoul, Korea.
- 2Yongin Mental Hospital, Yongin, Korea.
- 3Bugok National Hospital, Changnyung, Korea.
- 4Division of Molecular & Life Science, College of Science and Technology, Hanyang University, Ansan, Korea.
- 5Department of Neuropsychiatry, College of Medicine, Hanyang University, Seoul, Korea. swroh@hmc.hanyang.ac.kr
- 6Department of Neuropsychiatry, College of Medicine, Hallym University, Seoul, Korea.
Abstract
OBJECTIVES
The purpose of this study is to evaluate the pathophysiology of alcoholics by investigating the differences in frequency of Aldehyde Dehydrogenase 2(ALDH2) genotypes and ALDH2 alleles between patients with alcohol dependence and controls, and the differences of drinking and personality traits in Korean male alcoholics with ALDH2 genotype variances.
METHODS
The authors selected 98 patients with alcohol dependence and 53 controls. Self-report questionnaires for acute reponses after alcohol ingestion, the AUI(Alcohol Use Inventory), and the NEO-PI-R(NEO Personality Inventory Revised) were given to all patients with alcohol dependence. ALDH2 genotypes were typed with Mbo II RFLP(Restriction Fragment Length Polymorphism) method in 53 controls and 98 patients with alcohol dependence. The authors divided alcoholic patients into two groups according to the presence of variant ALDH22 allele; normal ALDH2 alcoholics(N=87) and variant ALDH2 alcoholics(N=11).
RESULTS
1) The genotypic frequencies of subjects with ALDH21/1 were higher and those with ALDH21/2 and ALDH22/2 were lower in patients than in controls. 2) Alcohol dependence could be found in ALDH22/2 homozygote individuals. 3) Variant ALDH2 alcoholics had more family problems in the AUI than normal ALDH2 alcoholics. 4) Variant ALDH2 alcoholics experienced more flushing and cardiovascular responses after alcohol ingestion than normal ALDH2 alcoholics. 5) Variant ALDH2 alcoholics had less altruistic personality traits in the NEO-PI-R than normal ALDH2 alcoholics. 6) Variant ALDH2 alcoholics tended to have more tolerance to alcohol than normal ALDH2 alcoholics.
CONCLUSION
Variant ALDH22 allele might play a protective role in the pathogenesis of alcohol dependence and there were several significant differences of drinking and personality traits in Korean male alcoholics with ALDH2 genotype variances.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Genetic Frequencies of Aldehyde Dehydrogenase 2 in Korean patients with Alcohol Dependence
- Epileptic Seizure Due to Disulfiram Treatment
- Analysis of Breath Alcohol Degradation and Alcohol Metabolic Enzymes in a Korean Male Population
- Association of Genetic Polymorphisms of Aldehyde Dehydrogenase II and CYP2E1 and Clinical Characteristics of Patients with Alcohol Dependence
- Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea
