Korean J Biol Psychiatry.
2008 Nov;15(4):275-287.
Depression and Coronary Artery Disease(I): Pathophysiologic Mechanisms
- Affiliations
-
- 1Department of Psychiatry, Chonnam National University Medical School and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea.
- 2Department of Psychiatry, Chonnam National University Medical School and Clinical Trial Center, Chonnam National University Hospital, Gwangju, Korea. jsyoon@chonnam.ac.kr
Abstract
- Depression and coronary artery disease are both highly prevalent diseases. Many previous studies suggest that depression is a common comorbid condition in patients with coronary artery disease and has a significant negative impact on the onset, course, and prognosis of coronary artery disease. However, the exact mechanisms that underlie the association between these two diseases remain unclear. Pathophysiologic mechanisms that may explain the effect of depression on coronary artery disease include hypercoagulability, hypothalamus-pituitary-adrenal axis and autonomic nervous system dysregulation, altered inflammatory response. On the contrary, pathophysiologic mechanisms in coronary artery disease that affect depression are less well known. It is also suggested that both diseases may share a common genetic vulnerability. The authors reviewed the literature on the pathophysiologic relationships of depression and coronary heart disease.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The Effect of Depression on Aggression in Patients with Coronary Artery Disease
- Relation between Ischemia on Exercise Testing and on Holter Monitoring
- Aspiration Thromboembolectomy in the Management of Acute Coronary Occlusion during Pertaneous Transluminal Coronary Angioplasty
- Spontaneous Coronary Artery Dissection and Woven Coronary Artery: Three Cases and a Review of the Literature
- A Case of Single Coronary Artery c Effort Angina
