Korean J Asthma Allergy Clin Immunol.  2005 Sep;25(3):228-230.

A Case of Diclofenac-Induced Anaphylaxis with Elevated Serum Tryptase

Abstract

Diclofenac is a non-steroid anti-inflammatory drug (NSAID), which belongs to the phenylacetic acid group. It is commonly used in inflammatory conditions of various etiologies, degenerative joint disease, rheumatoid arthritis and in many other painful conditions. The most common adverse effects of NSAIDs are gastritis, peptic ulceration and depression of renal function, all of which result primarily from prostaglandin inhibition. Allergic reactions have been reported in 0.4% of patients taking diclofenac, and anaphylaxis to diclofenac is rare. We experienced a case of diclofenac-induced anaphylaxis with elevated serum tryptase, in which the oral aspirin challenge test and the skin test with various NSAIDs were negative.

MeSH Terms

Anaphylaxis*
Anti-Inflammatory Agents, Non-Steroidal
Arthritis, Rheumatoid
Aspirin
Depression
Diclofenac
Gastritis
Humans
Hypersensitivity
Joint Diseases
Peptic Ulcer
Skin Tests
Tryptases*
Anti-Inflammatory Agents, Non-Steroidal
Aspirin
Diclofenac
Tryptases