Korean J Asthma Allergy Clin Immunol.  2007 Sep;27(3):186-189.

A Case of IgA-Associated Leukocytoclastic Vasculitis Treated with Dapsone in the Elderly

Abstract

We report a case of elderly patient with IgA-associated leukocytoclastic vasculitis who was successfully treated with dapsone. A 75-year-old Korean female patient who had suffered from asthma visited because of multiple purpura, vesicle, and bullae on her extremities. She also complained of pitting edema, especially on the lower extremities. She was diagnosed as IgA-associated leukocytoclastic vasculitis by skin biopsy and treated successfully with steroid. How- ever, skin lesions recurred after tapering steroid. We restarted high-dose steroid and the lesions showed improvement. However, skin lesions were refractory to lower-dose steroids, and also refractory to colchicine treatment. Dapsone (50 mg daily) induced dramatic improvement of her cutaneous vasculitis, proteinuria and edema.

MeSH Terms

Aged*
Asthma
Biopsy
Colchicine
Dapsone*
Edema
Extremities
Female
Humans
Immunoglobulin A
Lower Extremity
Proteinuria
Purpura
Purpura, Schoenlein-Henoch
Skin
Steroids
Vasculitis*
Colchicine
Dapsone
Immunoglobulin A
Steroids