J Korean Pediatr Soc.  1999 Nov;42(11):1574-1578.

Dapsone in a Case with Chronic Recurrent Henoch-Sch nlein Purpura

• Choi J
• Lee SJ
• Koh DK

Abstract

The most clearly delineated condition with prominent cutaneous leukocytoclastic vasculitis which presents to a pediatrician is Henoch-Sch nlein purpura. There is general agreement that in Henoch-Sch nlein syndrome the skin manifestations have a very benign long-term course and that corticosteroids are of little value. Dapsone appears to be of special value in diseases characterized by an accumulation of polymorphonuclear neutrophils notably leukocytoclastic vasculitis. In the pediatric literature, however, no information is available on the use of this sulfone in Henoch-Sch nlein purpura. We report a case of Henoch-Sch nlein purpura in a 14-year-old female patient who presented with chronic recurrent skin manifestation and responded to dapsone for two years.

Keyword

Henoch-Sch nlein Purpura; Leukocytoclastic vasculitis; Dapsone

MeSH Terms

Adolescent
Adrenal Cortex Hormones
Dapsone*
Female
Humans
Neutrophils
Purpura*
Skin Manifestations
Vasculitis
Vasculitis, Leukocytoclastic, Cutaneous
Adrenal Cortex Hormones
Dapsone