Korean J Asthma Allergy Clin Immunol.
2010 Sep;30(3):184-192.
Pathophysiology and Therapy of Pruritus in Allergic and Atopic Diseases
Abstract
- Pruritus, briefly defined as an unpleasant sensation provoking the desire to scratch, is a major characteristic and one of the most debilitating symptoms in allergic diseases and atopic dermatitis. Although recent observations have clearly improved our knowledge of the pathophysiology of pruritus, it is still too complex involving neurophysiological and neuroimmunological aspects. In this review, we summarize the current information regarding the role of mediators and receptors related to trigger or inhibit pruritus, and the management of pruritus in allergic and atopic disease.
